نتایج جستجو برای: pyrazole derivative
تعداد نتایج: 66771 فیلتر نتایج به سال:
BACKGROUND The plant pathogenic fungus (such as Gibberella zeae, Fusarium oxysporum and Cytospora mandshurica) causes devastating disease in agriculture. The pathogenic fungus is responsible for billions of dollars in economic losses worldwide each year. In order to discover new fungicidal molecule with good fungicidal activity against G. zeae, F. oxysporum, and C. mandshurica, we sought to com...
The correlation between the in vivo toxicity and in vitro mutagenicity of dimethylnitrosamine and the activity of dimethylnitrosamine demethylase I (DMND I) after pyrazole treatment of rats was studied. The biological effects of pyrazole were measured either as toxicity to the rats or as mutations to Salmonella TA 92. A dose-response relationship was observed between DMND I activity and the adm...
Argininosuccinate synthase (ASS) is the rate-limiting enzyme in the urea cycle. Along with nitric oxide synthase (NOS)-2, ASS endows cells with the L-citrulline/nitric oxide (NO·) salvage pathway to continually supply L-arginine from L-citrulline for sustained NO· generation. Because of the relevant role of NOS in liver injury, we hypothesized that downregulation of ASS could decrease the avail...
A series of aluminium complexes containing anilido-pyrazolate ligands is described. Reactions of four anilido-pyrazolate ligand precursors, HNPhPz, HNPhTriMePz, HNPhOMePz, or HNPhSMePz [HNPhPz = ortho-C6H4(NH-phenyl)(1-pyrazole); HNPhTriMePz = ortho-C6H4(NH-2,4,6-trimethylphenyl)(1-pyrazole); HNPhOMePz = ortho-C6H4(NH-2-methoxyphenyl)(1-pyrazole); HNPhSMePz = ortho-C6H4(NH-2-methylthiophenyl)(1...
The stability constants of the complexes of Cu (II), Co (II) and Ni (II) ions with 3-(3’-nitrophenyl)4-(4"-chlorobenzoyl)-5-(2-hydroxyphenyl) pyrazole (L1), 3-(4’-chlorophenyl)-4-(4"-chlorobenzoyl)-5-(2hydroxyphenyl) pyrazole (L2), 3-(4’-methoxyphenyl)-4-benzoyl-5-(2-hydroxyphenyl) pyrazole (L3), 3(4-bromophenyl)-4-furoyl-5-(2-hydroxyphenyl) pyrazole (L4) have been determined by the pH-metric m...
In the title mol-ecule, C(22)H(21)N(3), the isoquinoline ring is almost planar [maximum deviation = 0.046 (1) Å] and makes dihedral angles of 52.01 (4) and 14.61 (4)° with the pyrazole and phenyl rings, respectively. The phenyl ring and the pyrazole ring are twisted by 44.20 (6)° with respect to each other. The terminal C atoms of both of the ethyl groups attached to the pyrazole ring are disor...
The title compound, [Fe(C(11)H(11)N(2)O)(2)], crystallizes with two independent mol-ecules in the asymmetric unit which have have different conformations. In one mol-ecule, the two ferrocene cyclo-penta-dienyl rings are fully eclipsed and the two pyrazole rings are syn to each other; in the other, the two cyclo-penta-dienyl rings are synclinal and the pyrazole rings are anti. In both mol-ecules...
Pyrazole dimer is observed for the first time in a free jet expansion. Its IR-active N−H stretching vibration is shifted by −269 cm−1 relative to the monomer. Along the 600 mm slit jet expansion, the average number density of pyrazole dimers is ≈ 10 cm−3. Exploratory quantum chemical calculations including electron correlation are in good agreement with the observed frequency shift and confirm ...
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