Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identified by chromosome banding analysis and confirmed by fluorescence in situ hybridization analysis o...

We studied 201 pregnancies that were established by in vitro fertilization and embryo transfer (IVF-ET) and compared the frequency of cytogenetic abnormalities with that found in a large control population matched for indication group (advanced maternal age) and time of sampling. A total of 252 IVF-ET fetuses were cytogenetically analysed by either chorionic villus sampling (CVS; n = 80) or amn...

Recurrent non-random balanced chromosomal translocation, usually involving the immunoglobulin heavy chain (IgH) gene or an immunoglobulin light chain gene and a proto-oncogene, which results in the overexpression of the latter under the control of an enhancer or promoter of the former, is a hallmark of many types of non-Hodgkin lymphoma (NHL) of B-cell origin. However, translocations between Ig...

TAL1 gene rearrangements have been described in approximately 25% of children with T cell acute lymphoblastic leukemia (ALL). Three percent of these rearrangements are the result of a reciprocal translocation, t(1;14)(p34;q11). The remainder of these rearrangements are submicroscopic and involve a nearly precise 90-kilobase pair deletion of the TAL1 gene. Detection of these submicroscopic rearr...

The clinical and hematological characteristics and the prognostic significance of del(20q) were investigated in a consecutive series of 213 myeloid malignancies. In the analyses, the cases were divided into three subgroups according to diagnosis or four subgroups according to cytogenetic data. Patients in the myeloproliferative neoplasms subgroup had high WBCs and platelet counts at initial dia...

BACKGROUND Recalcitrant pyodermic lesions and neutrophilic dermatoses are often associated with subclinical myelodysplastic syndrome (MDS). In this case series, we assessed the diagnostic importance of karyotypic analysis of bone marrow cells in 4 patients with MDS-associated pyodermic eruptions treated at our university hospital. Karyotypic analysis was performed in bone marrow cells and perip...

The Philadelphia chromosome was first discovered in Philadelphia in 1960. It corresponds to shortened chromosome 22 resulting from reciprocal translocation between long arm of chromosome 9 and short arm of chromosome 22, which is designated as t(9;22)(q34;q11). This gives rise to a BCR/ABL fusion gene, that juxtaposes the ABL1 gene on chromosome 9 (region q34) to a part of the BCR ("Breakpoint ...

= ∑ n1>...>nr>0 q11 . . . qirnrn1 1 . . . n −sr r , with q a root of unit and i = (i1, . . . , ir) a composition. These sums converge when s1 > 1. To study simultaneously these families of polyzêtas, the colored Hurwitz polyzêtas, for a composition s = (s1, . . . , sr) and a tuple of complex numbers ξ = (ξ1, . . . , ξr) and a tuple of parameters in ]−∞; 1[, t = (t1, . . . , tr), are defined by [6]