Background: Artesunate-amodiaquine (AS-AQ) is one of the most widely used artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium falciparum malaria in Africa. We investigated the impact of different dosing strategies on the efficacy of this combination for the treatment of falciparum malaria. Methods: Individual patient data from AS-AQ clinical trials were pooled using...

A study to measure adherence to artesunate and amodiaquine (AS+AQ) therapy in patients treated for uncomplicated malaria in community health centres (CHC) was conducted in Sierra Leone. Patients/caretakers were interviewed and remaining AS+AQ tablets at home after the last treatment dose were counted. Persons leaving CHCs with an AS+AQ prescription were also interviewed (exit interviews). In to...

This study aimed to examine the efficacy of epirubicin-loaded gelatin hydrogel (EPI-H) in the treatment of superficial urothelium carcinoma. Hydrogel was prepared by Schiff base-crosslinking of gelatin with glutaraldehyde. EPI-H exhibited high entrapment efficiency (59.87% ± 0.51%). EPI-H also increased epirubicin accumulation in AY-27 cells when compared with the effect of aqueous solutions of...

We examine factors controlling the photochemical oxidation of SO2 in tropospheric aerosols using a gas-aqueous photochemical model. Over a range of liquid water contents (3x10 -4g H20 m -3 to 9 g H20 m -3) and pH values (0 to 8), we find that H202(aq) and O3(aq) provide the major sinks for SO2 in the aqueous phase when pH is held constant at below 5 and larger than 6, respectively. OH(aq) may b...

Abstract. In liquid cloud droplets, superoxide anion (O2(aq)-) is known to quickly consume ozone (O3(aq)), which relatively insoluble. The significance of this reaction as a tropospheric O3 sink sensitive the abundance O2(aq)- and therefore production its main precursor, hydroperoxyl radical (HO2(aq)). aqueous-phase oxidation oxygenated volatile organic compounds (OVOCs) major source HO2(aq) in...

This paper compares the current density (J) versus applied bias (V) of self-assembled monolayers (SAMs) of three different ethynylthiophenol-functionalized anthracene derivatives of approximately the same thickness with linear-conjugation (AC), cross-conjugation (AQ), and broken-conjugation (AH) using liquid eutectic Ga-In (EGaIn) supporting a native skin (~1 nm thick) of Ga(2)O(3) as a nondama...

A systematic study of ΔG(aq)/pK(a) for monoprotic, diprotic, and triprotic acids has been carried out based on DFT/aug-cc-pVTZ combined with CPCM and SMD solvation modeling. All DFT/cavity set combinations considered showed similar accuracy for ΔG(aq)(1)/pK(a1) (70% within ±2.5 kcal mol(-1) of experiment) while only the M05-2X/Pauling cavity combination gave reasonable results for ΔG(aq)(2)/pK(...

s: Soda-anthraquinone (soda-AQ) alkaline sulfiteanthraquinone (AS-AQ) and ASAM (alkaline sulfiteanthraquinonemethanol) cooking of southern cattail whole stem and bark from Sudan was carried out under different conditions and pulps with acceptable to good screened yields and very good mechanical properties were attained. The southern cattail whole stems gave satisfactory mechanical properties wi...

absrtact   aim and background: autistic traits may present in normal population without interfering with daily functionings. the present investigation is to find factor structure and validation of broad autism phenotype questionaire (bapq) and comparing psychometric structures of it with autsim quotient (aq). methods and materials: in this correlational study, 351 students in shahid beheshti un...

Background: This study investigated the prevalence of antimalarial drug resistance markers in P. falciparum isolates, involving the detection of mutations at the mdr1-86, which associates with amodiaquine resistance, and dhfr mutations associated with SP resistances. Methods: The dot-blot/probe hybridization was used to determine multidrug resistance (mdr1-86) and assess the correlation of Amod...