Quinoline, a nitrogen-containing heterocyclic molecule, has emerged as an important scaffold in medicinal chemistry due to its diverse pharmacological effects. The fused quinazoline nucleus particular garnered attention for potent properties, including antibacterial, antiviral, anti-cancer, anti-inflammatory, antioxidant, and anticonvulsant mechanism of action these quinoline derivatives is spe...

A novel series of quinazoline derivatives were designed, synthesized, and evaluated as multikinase inhibitors. Most these compounds showed antiproliferation activities several human cancer cell lines exhibited inhibition efficacy against the estimated glomerular filtration rate (EGFR) in nanomolar level. Among those compounds, compound B5 (also named SIPI6473) displayed maximum effect, thus was...

In search of potent cholinesterase inhibitors, we have carried out the synthesis and biologically evaluation of various benzaldehyde based 2,3-dihydroquinazolin-4(1H)-one derivatives. In vitro assay results revealed that all the synthesized compounds showed activity against both enzymes (AChE and BChE) and in few cases, the inhibition activity was even higher than or comp...

Three quinazoline based small molecules showed global upregulation of miRNA expression with a selective enrichment of tumor suppressor miRNAs. The target genes of the upregulated miRNAs were predicted to be enriched for apoptotic pathways. Apoptotic induction following treatment with quinazoline compounds was confirmed by in cellulo studies. Thus, these small molecules having the core structura...

A sustainable approach for the synthesis of substituted quinazolines by sequential acceptorless dehydrogenative coupling 2-aminobenzyl alcohol with alcohols using new Pd(II)-NNO pincer-type complexes as catalysts was reported. Air-stable palladium(II) general formula [Pd(L)(PPh3)] (where L = 4-substituted methyl-2-pyrrolyl benzhydrazone ligands) were synthesized, and their compositions recogniz...