Sir,?The above article in the December 1937 issue interested me very much because it raises some other points. The patient was given nine 10-grain quinine injections intramuscularly,. thrice daily and on consecutive days. In the London School of Tropical Medicine and Hygiene they condemn most emphatically intramuscular injections of quinine. They say quinine causes tissue necrosis, much of the ...

Independent experimental manipulation of subjective intensity and hedonic tone is required if one wants to study their separate effects on brain activity and behavior. This is problematic because hedonic tone and subjective intensity are related, leading to a pleasantness change each time the stimulus intensity is altered. In the present study, a solution to this problem was explored by combini...

Until now, quinine has been used worldwide as the drug of choice for the emergency treatment of severe and complicated malaria. In fact, the long­ standing dependability of quinine has created a context of clinical confidence and reduced the per­ ceived threat of P. Jalciparum recrudescence where quinine and quinidine are available. However, in a situation of substantial loss of efficacy, it is...

OBJECTIVE To assess quantitatively the efficacy of quinine (as quinine sulphate) compared with placebo in the treatment of nocturnal leg cramps. DESIGN A meta-analysis of six randomised, double blind, crossover trials. SETTING Randomised trials that were available as of April 1994. SUBJECTS A total of 107 general ambulatory patients who suffered from regular nocturnal leg cramps from six ...

OBJECTIVE The purpose of this study was to determine the pharmaceutical quality of quinine preparations sold in Nigerian markets. MATERIALS AND METHODS The organoleptic and physicochemical properties of quinine tablets, as well as oral liquids and parenteral quinine preparations, were assessed according to British Pharmacopoeia (BP) and unofficial standards as recommended by the manufacturers...

Mice of the SWR/J (SW) strain avoid orally delivered sucrose octa-acetate (SOA), whereas the mice of the C3HeB/FeJ (C3) strain are insensitive to SOA. Mice of both strains and of a congenic strain (C3.SW) that shares more than 99% of the C3 genome, were tested in a taste-salient brief-access taste test for responses to SOA and quinine hydrochloride, before and after transection of the glossopha...