PURPOSE OF REVIEW This review discusses the use of the inhibitory quotient in light of therapeutic drug monitoring of antiretroviral drugs. The inhibitory quotient is a parameter that combines viral resistance data with drug exposure data, and has its main role in therapeutic drug monitoring of protease inhibitors in experienced patients. Data from recent clinical studies investigating inhibito...

For a finitely generated discrete group Γ, the Γ-sectors of an orb-ifold Q are a disjoint union of orbifolds corresponding to homomorphisms from Γ into a groupoid presenting Q. Here, we show that the inertia orbifold and k-multi-sectors are special cases of the Γ-sectors, and that the Γ-sectors are orbifold covers of Leida's fixed-point sectors. In the case of a global quotient, we show that th...

Previous studies found that humor and empathy are associated with interpersonal relationships. Particularly, Hampes (2001) reported that humor styles and empathy had a positive correlation in adults. The purpose of the study is to explore the link between empathy and humor use in teenagers and to investigate if gender differences exist as well. 115 adolescents between 11-12 years old participat...

We show that the quotient of a Hom-finite triangulated category C by the kernel of the functor HomC(T, −), where T is a rigid object, is preabelian. We further show that the class of regular morphisms in the quotient admit a calculus of left and right fractions. It follows that the Gabriel-Zisman localisation of the quotient at the class of regular morphisms is abelian. We show that it is equiv...