MOTIVATION The field of microarray data analysis is shifting emphasis from methods for identifying differentially expressed genes to methods for identifying differentially expressed gene categories. The latter approaches utilize a priori information about genes to group genes into categories and enhance the interpretation of experiments aimed at identifying expression differences across treatme...

Asymptotic analytical solutions are derived for the configuration posed by Quon [Phys. Fluids, 26, 632 (1983)] for diffusion-driven flow in a tilted square container when the diffusive parameter R is small. The key regions of the asymptotic structure are outlined and leading-order solutions are determined in most of those regions. The analysis follows that in Page & Johnson [J. Fluid Mech., 629...

Although studies show protective effects of 17beta-estradiol (E2) or prolactin (PRL) treatment in male rats after trauma-hemorrhage (TH), the mechanism of the salutary effects of these agents remains unknown. Because E2 modulates PRL receptor (PRL-R) expression in the liver, we examined whether E2 treatment after T-H has any effects on hepatic PLR-R gene expression. Male Sprague-Dawley rats wer...

OBJECTIVE There is still debate as to whether antiatherosclerotic effect of PPARgamma ligands is dependant on PPARgamma gene itself or some other pathway. METHODS AND RESULTS To investigate the effect of PPARgamma gene modulation on neointima formation after balloon injury, we delivered adenoviral vectors expressing the wild-type (WT) dominant negative (DN) PPARgamma, or a control gene (beta-...

Adrenocorticotrophin (ACTH) is the major regulatory hormone of steroid synthesis and secretion by adrenocortical cells. The actions of ACTH are mediated by its specific membrane receptor (ACTH-R). The human ACTH-R gene was recently cloned, allowing systematic determination of its sequence, expression and function in adrenal tumorigenesis. The presence of oncogenic mutations of the ACTH-R gene i...

Clustering is commonly used in the analysis of gene expression data to find groups of co–expressed genes. The definition of gene clusters is not very clear as genetic interactions are extremely complex. For this reason the relationship between clusters is very important as co–expressed genes can end up in different clusters. The neighborhood graph is a useful tool to visualize the cluster struc...

2. Introduction. Let SI C R" be a bounded domain with smooth boundary F. We consider the problem pd2tu — /LiAu — (p + A)V(V ■ u) + aV9 = 0 in ft x R+, (2.1) pcpdt9 — kA9 + adtV • u = 0 in fl x where u is a time-dependent deformation vector field, 6 is the normalized temperature, p, p, and cp are positive constants, 2/x + A > 0 (p the density, /i and A are Lame's constants, and cp is the specifi...

(a) Educational Building (RGL) (b) Simulation Testbed Figure 1: The actual research testbed at the University of Southern California and our simulator