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Activation of Src kinase has been implicated in the pathogenesis of acute brain, liver, and lung injury. However, the role of Src in acute kidney injury (AKI) remains unestablished. To address this, we evaluated the effects of Src inhibition on renal dysfunction and pathological changes in a murine model of AKI induced by ischemia/reperfusion (I/R). I/R injury to the kidney resulted in increase...

BACKGROUND The economic merit of universal prophylaxis and preemptive therapy in the management of cytomegalovirus (CMV) infection for serology positive (R+) kidney transplant patients remains undefined. We performed cost effectiveness and cost utility modeling comparing these two approaches. METHODS The incidence of CMV infection under universal prophylaxis and preemptive therapy was determi...

1 Spackmann, D. H., W. H. Stein, and S. Moore, Anal. Chem., 30, 1190 (1958). 12 Tsugita, A., and H. Fraenkel-Conrat, these PROCEEDINGS, 46, 636 (1960). 13 Fraser, D., J. Biol. Chem., 227, 711 (1957). 14 In order to express the molar content of each amino acid as the percentage of the total amino acids, the value listed in Tables 1 and 2 should be divided by a factor of 1.4. 15 Roberts, R. B., D...

BACKGROUND AND OBJECTIVES Patients with allergic disorders such as allergic rhinitis or asthma have been reported to be at increased risk for atherosclerosis. In this study, we evaluated the relationships between peripheral eosinophil count and degree of albumin excretion rate, which is a useful marker of cardiovascular mortality as well as diabetic nephropathy in patients with type 2 diabetes....