Rabies vaccines based on live attenuated rabies viruses or recombinant pox viruses expressing the rabies virus (RV) glycoprotein (G) hold the greatest promise of safety and efficacy, particularly for oral immunization of wildlife. However, while these vaccines induce protective immunity in foxes, they are less effective in other animals, and safety concerns have been raised for some of these va...

The Vero cell is the continuous line used as a substrate for many viral vaccines manufacturing including Rabies vaccine. Pitman and PV-11 strains of rabies virus are commonly production vaccines. In our study PV - 11 strain seed derived inactivated Anti Vaccines (Lyophilized). working bank lot were prepared tested its sterility mycoplasma contamination. this roller bottle method micro carrier (...

P reexposure rabies vaccination is recommended for individuals who are more likely to be exposed to rabies virus than the general public. 1 This vaccination series consists of 3 doses of vaccine administered IM or intradermally (ID), which permits postexposure vaccination to consist of 3 doses of vaccine rather than 5 and eliminates the need for postexposure administration of human rabies immun...

This review focuses on the immunization of animals as a means of preventing human diseases (zoonoses). Three frameworks for the use of vaccines in this context are described, and examples are provided of successes and failures. Framework I vaccines are used for protection of humans and economically valuable animals, where neither plays a role in the transmission cycle. The benefit of collaborat...

The inactivation dynamics of rabies virus (PV strain) by binary ethylenimine, and the immunogenic properites and the stability of the vaccines prepared using this agent, were studied. Binary ethylenimine at a final concentration of 0.01 M was prepared wtih 2-bromoethylamine hydrobromide in alkaline solutions, either separately from or in suspensions of rabies virus propagated in BHK cells. The ...

Between August 1993 and September 1994 we documented serological responses of coyotes (Canis latrans) vaccinated with two commercial rabies vaccines licensed for use in domestic dogs. Serologic responses were documented by testing for rabies virus neutralizing antibodies with the rapid fluorescent focus inhibition test (RFFIT) at 30, 90, 180, 270, and 365 days post-vaccination. All coyotes vacc...

PURPOSE To fight animal rabies, Moroccan veterinary authorities organize annual dog mass vaccination campaigns using Rabivac vaccine, an inactivated adjuvanted cell culture veterinary rabies vaccine. Two experiments were undertaken to assess the efficacy and immunogenicity of Rabivac. MATERIALS AND METHODS The first experiment involved 13 caged dogs (8 vaccinated and 5 negative controls). Dog...

The number of human rabies cases acquired from dog bites constitutes a high proportion of the total rabies cases in China, although the number of human rabies cases has gradually decreased in recent years. The pivotal role of dogs in the spread of rabies indicates that controlling and preventing canine rabies could be a key step in eradicating human rabies in China. The primary aims of this rev...

Vaccines are subject to requirements that regulate their quality and safety. Due to their biological origin, vaccines are complex products which can be influenced by various factors. As a result, each batch of the finished product is tested on potency and safety. the use of animals in batch release testing is a regulatory obligation and represents around 80% of the total number of animals used ...

OBJECTIVE To review the safety and immunogenicity of pre-exposure rabies prophylaxis (including accelerated schedules, co-administration with other vaccines and booster doses), its cost-effectiveness and recommendations for use, particularly in high-risk settings. METHODS We searched the PubMed, Centre for Agriculture and Biosciences International, Cochrane Library and Web of Science database...