Adaptive responses can be induced in cells by very low doses of ionizing radiation resulting in an enhanced resistance to much larger exposures. The inhibitor of apoptosis protein, survivin, has been implicated in many adaptive responses to cellular stress. Computerized axial tomography used in image-guided radiotherapy to position and monitor tumor response uses very low radiation doses rangin...

Malignant fibrous histiocytoma (MFH) is a rare neoplasm exhibiting a propensity for aggressive clinical behavior. Effective treatment modality is surgical resection with wide margins, but its rate of recurrence and metastasis is still high. Early detection and complete excision of the tumor is necessary. A MFH of the occipital developed in a 51-year-old woman eight years after surgery and radia...

Background: Radiation-induced lung injury is a refractory side effect in lung cancer radiotherapy, the mechanism still remains unclear, hence an appropriate animal mode may become useful to investigate it. Materials and Methods: 50 female Wistar rats were randomly divided into 5 groups, average 10 rats/cage: A. control group B. 3Gy×10f C. 6Gy×5f D. 12.5Gy×1f E.15.3Gy×1f....

background: the aim of the present study was to evaluate the radioprotective effect of grewia asiatica fruit pulp extract (gae) on swiss albino mice exposed to gamma radiation. in the present study radioprotective efficacy of grewia asiatica (rich in anthocyanin, carotenes, vitamin c, etc.) was studied against radiation induced biochemical alterations in mice cerebrum. materials and methods: fo...

BALB/c mice are susceptible to radiation-induced mammary tumors as well as lymphomas. We investigated the effects of the p53 deficient allele and of X-irradiation on the tumor spectrum in the BALB/c background. Substantially all p53 -/-animals died of thymic lymphomas before 36 weeks of age, while none of the p53 +/+ animals died during that period. At this age, mortalities of p53 +/- females a...

BACKGROUND Synovial sarcoma is a malignant tumor of soft tissue that is rarely found in the head and neck. Even less common are metastasis within the head and neck. METHODS We describe a case of a delayed metastatic synovial sarcoma to the scalp. A man who had been diagnosed and treated 16 years previously for monophasic synovial sarcoma of the groin, presented with a new scalp lesion confirm...

The effect of radiation therapy on tumor growth and on specific immune resistance to tumor growth was investi gated in mice actively sensitized to a syngeneic sarcoma. While radiation was therapeutic for tumor growth in the radiated field, it was also found that extensive-field radia tion, but not limited-field radiation, could facilitate the growth of tumors in unradiated parts of the animal. ...

background: ionizing radiation induces the production of reactive oxygen species (ros), which play an important causative role in cell death. wholebody exposure of mice to gamma radiation leads to diminution of tissue antioxidant defense systems increases the peroxidative damage to membrane lipids and damages the haematopoietic and gastrointestinal systems. tempol (tpl), a cell membranepermeabl...