Peripheral nerve injury causes spontaneous and long-lasting pain, hyperalgesia, and allodynia. Excitatory amino acid receptor-dependent increases in descending facilitatory drive from the brainstem rostral ventromedial medulla (RVM) contribute to injury-evoked hypersensitivity. Although increased excitability likely reflects changes in synaptic efficacy, the cellular mechanisms underlying injur...

Atmospheric turbulence has significant influences on both the trajectories and strengths of wake vortices. In this paper, a quasi-wavelet method is used to generate a random atmospheric turbulence field based on the von Kármán spectrum, in which atmospheric turbulence is represented by groups of random eddies. An inviscid wake vortex system, out-of-ground effect or in-ground effect, is immersed...

PURPOSE To determine whether combining structural (optical coherence tomography, OCT) and functional (standard automated perimetry, SAP) measurements as input for machine learning classifiers (MLCs; relevance vector machine, RVM; and subspace mixture of Gaussians, SSMoG) improves diagnostic accuracy for detecting glaucomatous eyes compared with using each measurement method alone. METHODS Six...

Abstract In previous works, we have derived a Running Vacuum Model (RVM) for string Universe, which provides an effective description of the evolution 4-dimensional string-inspired cosmologies from inflation till present epoch. context this “stringy RVM” version, it is assumed that early Universe characterised by purely gravitational degrees freedom, massless multiplet, including antisymmetric ...

Surface settlement is one of the key engineering issues during shield construction process. In order to accurately predict surface settlement, this paper proposes a new machine learning method based on relevance vector (RVM), principal component analysis (PCA), and particle swarm optimization (PSO). Taking Beijing Metro Line 6 as case study, PCA-PSO-RVM model used make prediction compared with ...

We have previously shown that the balance of electrically evoked descending brainstem control of spinal nociceptive reflexes undergoes a switch from excitation to inhibition in preadolescent rats. Here we show that the same developmental switch occurs when μ-opioid receptor agonists are microinjected into the rostroventral medulla (RVM). Microinjections of the μ-opioid receptor agonist [D-Ala(2...

The rostral ventromedial medulla (RVM) is part of descending circuitry that modulates nociceptive processing at the level of the spinal cord. RVM output can facilitate pain transmission under certain conditions such as inflammation, and thereby contribute to hyperalgesia. Evidence suggests that substance P and activation of neurokinin-1 (NK-1) receptors in the RVM are involved in descending fac...

We study the general phenomenon of randomorganization using a vortex system.When a periodic shearwith a small shear amplitude dinp is applied tomany-particle (vortex) assemblies with a random distribution, the particles (vortices) gradually self-organize to avoid future collisions and transform into an organized configuration. This is detected from the time-evolution of the voltageV t ( ) (aver...

A novel kernel framework for hyperspectral image classification based on relevance vector machine (RVM) is presented in this paper. The new feature extraction algorithm based on Mexican hat wavelet kernel non-negative matrix factorization (WKNMF) for hyperspectral remote sensing images is proposed. By using the feature of multi-resolution analysis, the new method of nonlinear mapping capability...

Prostaglandin E2 (PGE2) produced in the medial preoptic region (MPO) in response to immune signals is generally accepted to play a major role in triggering the illness response, a complex of physiological and behavioral changes induced by infection or injury. Hyperalgesia is now thought to be an important component of the illness response, yet the specific mechanisms through which the MPO acts ...