Cancers are the uncontrolled growth of cells or tumors, and it is one leading causes death all over world. Currently, available synthetic drugs such as cisplatin, doxorubicin fluorouracil reported to have notable side effects in living tissues (skin irritations, dry cracked skin, mouth sores). So researchers scrutinizing for alternative medications overcome these effects. Plants vital sources m...

Eosinophil accumulation has been associated with the pathogenesis of numerous allergic inflammatory disorders. Despite the great interest in this response, many aspects of eosinophil accumulation remain unknown. This is particularly true with respect to tissue-specific mechanisms that may regulate the accumulation of eosinophils in different organs. This study addressed this issue by investigat...

background: wound healing of burned skin remains a major goal in public health. previous reports showed that the bone marrow stem cells were potent in keratinization and vascularization of full thickness skin wounds. methods: in this study, mesenchymal stem cells were derived from rat adipose tissues and characterized by flowcytometry. staining methods were used to evaluate their differentiatio...

Abstract Interstitial fluid (ISF) is a body that fills, surrounds cells and contains various biomarkers, but it has been challenging to extract ISF in reliable sufficient amount with high speed. To address the issues, we developed tilted microneedle collecting system (TMICS) fabricated by 3D printing. In this system, (MN) was inserted at 66° skin TMICS so MN length could be extended within safe...

The penetration rates of 10 hydrophobic solvents through the excised abdominal rat skin were quantitatively determined by using the in vitro method reported previously. The hydrophobic solvents studied were benzene, toluene, ethylbenzene, o-xylene, styrene, n-pentane, 2-methylpentane, n-hexane, n-heptane and n-octane. There was a great diversity in the ability of the hydrophobic solvents to pen...

The aim of this study was to prepare solid lipid microspheres (SLM) of octyl methoxy cinnamate (2-ethylhexyl-p-methoxy cinnamate; OMC) to achieve controlled release, decrease penetration of this UV absorber from skin and improve its photostability. The influence of the carrier on the rate of release was studied in vitro with a cellulose acetate membrane and in vivo from excised rat skin with Fr...

We present sub-millimeter wave reflectometry of an experimental rat skin burn model obtained by the Terahertz Time-Domain Spectroscopy (THz-TDS) technique. Full thickness burns, as confirmed by histology, were created on rats (n = 4) euthanized immediately prior to the experiments. Statistical analysis shows that the burned tissue exhibits higher reflectivity compared to normal skin over a freq...

Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsion (NE) of lornoxicam (LRX) were prepared for the treatment of painful and inflammatory conditions of the skin. Compritol® 888 ATO, Lanette® O and oleic acid were used as solid and liquid lipids. SLN, NLC and NE were found physically stable at various temperatures for 6 months. Case I diffusional drug release was...

In the present study a new alcohol derivative of tetrahydrogeraniol (THG), an acyclic monoterpene, has been prepared by using Grignard reagent and methyl cyclopropyl ketone. Penetration enhancing effects of THG and the synthesized derivative 5,9-dimethyl-2-cyclopropyl-2-decanol (DICNOL) on the transdermal penetration of 5-fluorouracil (5-FU) and tramadol hydrochloride (tramadol HCl) across the ...

Dermal 7alpha- and 7beta-hydroperoxycholest-5-en-3beta-ols (cholesterol 7alpha- and 7beta-hydroperoxides), regarded as good aging markers in the rat (Ozawa, N., Yamazaki, S., Chiba, K., Aoyama, H., Tomisawa, H., Tateishi, M., and Watabe, T. (1991) Biochem. Biophys. Res. Commun. 178, 242-247), were reduced in the presence of glutathione (GSH) with concomitant formation of GSSG by cytosol from ra...