In the clinic, the relative biological effectiveness (RBE) value of 1.1 has usually been used in relation to the whole depth of the spread-out Bragg-peak (SOBP) of proton beams. The aim of this study was to confirm the actual biological effect in the SOBP at the very distal end of clinical proton beams using an in vitro cell system. A human salivary gland tumor cell line, HSG, was irradiated wi...

BACKGROUND The skin is considered a critical organ at risk in carbon ion radiotherapy (CIRT) for locally advanced malignant bone and soft tissue tumors (MBSTs). The predictive factors for acute skin reactions after CIRT have not been investigated. The present study aimed to identify these factors and evaluate the correlation between the severity of acute skin reactions and skin dose parameters....

The aim of this study was to evaluate the dosimetric characteristics a semi-customized tongue displacement device ( SC TDD) fabricated using 3D printer for patients receiving unilateral head and neck irradiation with intensity-modulated proton therapy (IMPT) assess its feasibility as beam stopper compared standard mouthpiece S MP). Seven consecutive patients, three tonsil cancer, four oral cavi...

BACKGROUND Various types of radiation effects in mammalian cells have been studied with the aim to predict the radiosensitivity of tumours and normal tissues, e.g. DNA double strand breaks (DSB), chromosome aberrations and cell reproductive inactivation. However, variation in correlations with clinical results has reduced general application. An additional type of information is required for th...

The radiobiological effectiveness of 160 MeV protons was measured relative to -Co y-rays, using Chineee hamster cells cultured in o&o. Separate experiments were performed witb cells irradiated in sWpem&m, or attached to plastk tisslre culture flasks. Proton irradiations were performed in the incident plateau of the depth dosepro6Uc~niththeBrPggpenksprendouttocoverlOcls.Inallcrrscstberdstlveblde...

One major rationale for the application of heavy ion beams in tumor therapy is their increased relative biological effectiveness (RBE) in the Bragg peak region. For dose prescription, the increased effectiveness has to be taken into account in treatment planning. Hence, the complex dependencies of RBE on the dose level, biological endpoint, position in the field etc. require biophysical models,...

BackgroundStereotactic ablative radiotherapy (SABR) is a treatment option for patients with lung tumors that employs fiducials to track during the breathing cycle. Currently, there paucity of data on how relative fiducial location and patient clinical characteristics impact tracking outcomes. This study aims identify factors reduce number tracked respiratory motion management SABR.MethodsAn IRB...

During adeno-associated virus (AAV) type 2 productive infections, the p19 promoter of AAV is activated by the AAV Rep78 and Rep68 proteins. Rep-induced activation of p19 depends on the presence of one of several redundant Rep binding elements (RBEs) within the p5 promoter or within the terminal repeats (TR). In the absence of the TR, the p5 RBE and the p19 Sp1 site at position -50 are essential...