Topical application of the tumor promoter 12-0-tetradecanoylphorbol13-acetate (TPA) to SENCAR mouse skin results within 48 h in a 3-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of gen erating the reactive oxygen species Superoxide and hydrogen peroxide. The antiinflammatory steroid fluocinolone acetonide, an inhibitor of TPAinduced hyperplasia, as well as the multiple sta...

Epidemiological and experimental data point to involvement of oxygen derived radicals in the pathogenesis of gynecological disorders, as well as in cancer development. The objective of the present study was to examine changes in activities and levels of copper/zinc superoxide dismutase (CuZnSOD) and lipid hydroperoxides (LOOH) in blood and endometrial tissue of patients diagnosed with uterine m...

Background. This study was aimed at comparing angiogenesis, seen as microvessel density (MVD) in subtypes of non-Hodgkin's lymphoma (NHL). Methods. In this study, 64 cases of NHL diagnosed over a three-year period were included along with 15 lymph node biopsies of reactive hyperplasia. NHLs were classified using REAL classification, and immunohistochemistry was performed for CD34 in all cases. ...

Nodular histiocytic/mesothelial hyperplasia (NHMH) is a very rare condition. It generally thought to be associated with repeated mechanical or chemical stimulation. This study reported NHMH papillary growth pattern in the ovary following high-intensity focused ultrasound (HIFU) treatment for uterine leiomyoma and adenomyosis. A 48-year-old female, who had history of undergoing HIFU 7 times aden...

We investigated age-related EBV(+) B-cell lymphoproliferations in the Western population. The clinical features, histology, immunophenotype, EBV-encoded RNA in situ hybridization, and clonality by PCR of T-cell receptor gamma and immunoglobulin genes were categorized in 122 EBV(+) lesions as follows: (1) reactive lymphoid hyperplasia; (2) polymorphic extranodal or (3) polymorphic nodal lymphopr...

Atherosclerosis, restenosis, and posttransplant graft atherosclerosis are characterized by endothelial damage, infiltration of inflammatory cells, and proliferation of smooth muscle cells. The CXCR3-activating chemokines interferoninducible protein 10 (IP10) and MIG (monokine induced by interferon) have been implicated in vascular repair and remodeling. The underlying molecular mechanisms, howe...

Objective(s): Peripheral giant cell granuloma (PGCG) is a reactive, proliferative, exophytic lesion developing on the gingiva and alveolar ridge, originating from the periosteum or periodontal membrane. The lesion develops mostly in adults, commonly in the lower jaw, with slight female predilection although is uncommon in children. Cases Report: Two boys, 11 and 8-years-old respectively, otherw...