The aim of this study was to determine the effects of lidocaine (LIDO) and dexmedetomidine (DEX) or their combination (LIDO-DEX), administered by constant-rate infusion (CRI), on the minimum alveolar concentration (MAC) of sevoflurane in dogs. Seven healthy mongrel dogs were used with a 2-week washout interval between treatments in this study. Anesthesia was induced with propofol and maintained...

Alpha-blockers and antibiotics are most commonly used to treat chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in clinical practice. Currently, increasing evidence also suggests acupuncture as an effective strategy. This network meta-analysis intended to assess the comparative efficacy and safety of acupuncture, alpha-blockers and antibiotics for CP/CPPS. Twelve trials involving 1203...

OBJECTIVES To provide a survey of the field of clinical research informatics (CRI), focusing in particular on significant developments over the past 3 years and the insights they provide about the progress and state of the field. METHODS An iterative "scoping review" of the literature published in scientific journals and conference proceedings that are relevant to CRI, from late 2009 to early...

BACKGROUND Proteinuria is the most important risk factor for IgA nephropathy progression. The purpose of this study is to evaluate the long-term outcome and risk factors for poor prognosis in childhood IgA nephropathy. METHODS Patients who were diagnosed with IgA nephropathy between 1972 and 1992 at the Tokyo Metropolitan Kiyose Children's Hospital were included. We analyzed risk factors for ...

To inform the UK antimicrobial resistance strategy, a risk assessment was undertaken of the likelihood, over a five-year time-frame, of the emergence and widespread dissemination of pan-drug-resistant (PDR) Gram-negative bacteria that would pose a major public health threat by compromising effective healthcare delivery. Subsequent impact over five- and 20-year time-frames was assessed in terms ...

BACKGROUND Exercise therapy encompasses a heterogeneous group of interventions. There continues to be uncertainty about the most effective exercise approach in chronic low back pain. PURPOSE To identify particular exercise intervention characteristics that decrease pain and improve function in adults with nonspecific chronic low back pain. DATA SOURCES MEDLINE, EMBASE, PsychInfo, CINAHL, an...

Marianne Trudel's contribution for the COVID-19 Special Issue. 
 Contribution de Trudel pour le numéro spécial COVID-19.

Cardio-respiratory instability (CRI) occurs frequently in acutely ill. If not identified and treated early, it leads to significant morbidity and mortality. Current practice primarily relies on vigilance of the clinical personnel for early recognition of CRI. Given limited monitoring resources available in critical care environment, it can be suboptimal. Thus, an "Early Warning Scoring" mechani...

Fig. 1. (a) Estimates of SVR12 achievement, medians with 95% CrIs, calculated by the Bayesian model. The numerical values of these estimates are as follows: SOF/LED-12 weeks, 93.17 (95% CrI: 98.35–99.76); SOF/LED-8 weeks, 77.84 (95% CrI: 93.64–98.71); SOF/DAC, 87.62 (95% CrI: 99.56–100); ARIOD, 83.42 (95% CrI: 93.88–97.93); and ARIODR, 93.15 (95% CrI: 97.27–99.12). (b) Histograms of rankings es...