نتایج جستجو برای: receptors of interleukin
تعداد نتایج: 21189198 فیلتر نتایج به سال:
Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease characterized by the persistence of activated myofibroblasts resulting in excessive deposition of extracellular matrix proteins and profound tissue remodeling. Myofibroblasts have been shown to arise from interstitial fibroblasts, epithelial to mesenchymal transition of type II alveolar epithelial cells, an...
Systemic inflammation causes learning and memory deficits through mechanisms that remain poorly understood. Here, we studied the pathogenesis of memory loss associated with inflammation and found that we could reverse memory deficits by pharmacologically inhibiting α5-subunit-containing γ-aminobutyric acid type A (α5GABA(A)) receptors and deleting the gene associated with the α5 subunit. Acute ...
conclusions increased serum levels of interleukins 6 and 8 as a predictive marker might be associated with unfavorable clinical outcome in patients with severe tbi. results comparing the serum levels of interleukins in two groups with favorable and unfavorable clinical outcomes showed that the mean serum levels of interleukins 6 and 8 in group with favorable outcome was 85.2 ± 51.6 and 52.2 ± 3...
NF-κB proteins are evolutionarily conserved master regulators of immune and inflammatory responses (Gilmore, 2006). They play critical roles in a wide array of biological processes including innate and adaptive immunity, oncogenesis and development. They are activated in response to ligation of many receptors including T-cell receptors, B-cell receptors, members of the tumor necrosis factor (TN...
Primary and Secondary Immunodeficiency Pyogenic Bacterial Infections in Humans With MyD88 Deficiency
PURPOSE OF THE STUDY. Myeloid differentiation protein 88 (MyD88) is a key downstream adapter for receptors of the innate immune system, including most Toll-like receptors (TLRs) and interleukin 1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens, and the goal of this study was to determine whether there are children with recurrent infections who ...
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