Sir: Dopamine agonists, such as carbidopa-levodopa, have utility in alleviating symptoms of movement disorders , e.g., parkinsonism, and can reduce distressing movement disturbances arising from a variety of other conditions , e.g., restless legs syndrome, and tremor arising from head injury. We report a case illustrating that utilization of a dopamine agonist can precipitate tics in a patient ...

Children suffering from acute rheumatic fever are usually treated with the hormone preparations, cortisone and A.C.T.H., or with salicylates. Almost always symptoms are rapidly alleviated and clinical signs of activity subside. In a number of cases discontinuance of treatment when the disease process seems to be quiescent is followed by an apparent recrudescence. This feature has become known a...

Chronic immunological complications of malaria include hyperreactive malarial splenomegaly (HMS) and quartan malarial nephropathy. HMS represents an abnormal immunological response to recurrent malarial infections as a result of defective T suppressor cell regulation. On the other hand, quartan malarial nephropathy, which usually presents in childhood with nephrotic syndrome, is not responsive ...

A rapid decrease in parasitaemia remains the major goal for new antimalarial drugs and thus, in vivo models must provide precise results concerning parasitaemia modulation. Hydroxyethylamine comprise an important group of alkanolamine compounds that exhibit pharmacological properties as proteases inhibitors that has already been proposed as a new class of antimalarial drugs. Herein, it was test...

Noncytopathic viruses use multiple strategies to evade immune detection, challenging a role for vaccine induced CTL in preventing microbial persistence. Recrudescence of neurotropic coronavirus due to loss of T cell-mediated immune control provided an experimental model to test T cell vaccination efficacy in the absence of Ab. Challenge virus was rapidly controlled in vaccinated Ab-deficient mi...

Background: Granulomatosis with polyangiitis (GPA) is a necrotizing vasculitis usually involving small blood vessels that has been described to rarely effect the meninges, presenting with headaches and in our case papilledema. Thickened dura mater may be seen on brain imaging and is an entity known as hypertrophic pachymeningitis. We present a case of isolated dural recrudescence of ANCA vascul...

Eastern equine encephalitis virus (EEEV; family Togaviridae, genus Alphavirus) epizootics are infrequent, but they can lead to high mortality in infected horses and humans. Despite the importance of EEEV to human and animal health, little is known about how the virus overwinters and reinitiates transmission each spring, particularly in temperate regions where infected adult mosquitoes are unlik...