BACKGROUND It is widely supposed, but not well-demonstrated, that cumulative advances in standard care have reduced recurrent stroke and cardiovascular events in secondary prevention trials. METHODS AND RESULTS Systematic search identified all randomized, controlled trials of medical secondary stroke prevention therapies published from 1960 to 2009. Randomized, controlled trials narrowly focu...

BACKGROUND AND PURPOSE Minor stroke and transient ischemic attack portend a significant risk of disability. Three possible mechanisms for this include disability not captured by the National Institutes of Health Stroke Scale, symptom progression, or recurrent stroke. We sought to assess the relative impact of these mechanisms on disability in a population of patients with transient ischemic att...

We propose a regression-based hot-deck multiple imputation method for gaps of missing data in longitudinal studies, where subjects experience a recurrent event process and a terminal event. Examples are repeated asthma episodes and death, or menstrual periods and menopause, as in our motivating application. Research interest concerns the onset time of a marker event, defined by the recurrent ev...

A variety of statistical methods are available to investigators for analysis of time-to-event data, often referred to as survival analysis. Kaplan-Meier estimation and Cox proportional hazards regression are commonly employed tools but are not appropriate for all studies, particularly in the presence of competing risks and when multiple or recurrent outcomes are of interest. Markov chain models...

A class of tests for the hypothesis that the baseline hazard function in Cox's proportional hazards model and for a general recurrent event model belongs to a parametric family C identical with {lambda(0)(.; xi): xi in Xi} is proposed. Finite properties of the tests are examined via simulations, while asymptotic properties of the tests under a contiguous sequence of local alternatives are studi...

BACKGROUND Patients who have had an unprovoked deep venous thrombosis (DVT) or pulmonary embolus (PE) are at a high risk for recurrent venous thromboembolism (VTE). Extended "life-long" anticoagulation has been recommended in these patients. However, the risk benefit ratio of this approach is controversial and the role of the direct oral anticoagulants (DOACs) and aspirin is unclear. Furthermor...

When conducting recurrent event data analysis, it is common to assume that the covariate processes are observed throughout the follow-up period. In most applications, however, the values of time-varying covariates are only observed periodically rather than continuously. A popular ad-hoc approach is to carry forward the last observed covariate value until it is measured again. This simple approa...