Between 1960 and 1977, 50 patients with agnogenic myeloid metaplasia were splenectomized. Twenty-five of 26 patients with painful splenomegaly, 4 of 9 patients with refractory hemolytic anemia, 4 of 10 patients with refractory thrombocytopenia, and 4 of 4 patients with portal hypertension showed significant benefit from the procedure. There were five immediate postoperative deaths. Four of thes...

Renovascular hypertension (RVH) is the most important cause of secondary hypertension and it is often due to occlusive lesion of renal arteries. RVH is precipitated by a hemodynamically significant stenosis of a renal artery or arteries (that is, a stenosis greater than 75% of the vessel lumen or 50% with poststenotic dilation). The frequency of renovascular hypertension is less than 1% in pati...

Management of portal hypertension in children has evolved over the past several decades. Portal hypertension can result from intrahepatic or extrahepatic causes. Management should be tailored to the child based on the etiology of the portal hypertension and on the functionality of the liver. The most serious complication of portal hypertension is gastroesophageal variceal bleeding, which has a ...