The emerging field of regenerative medicine will require a reliable source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue represents an abundant and accessible source of adult stem cells with the ability to differentiate along multiple lineage pathways. The isolation, characterization, and preclinical and clinical application of adipose-derived st...

A method for evolving programs that construct multicellular structures (organisms) is described. The paper concentrates on the difficult problem of evolving a cell program that constructs a fixed size French flag. We obtain and analyze an organism that shows a remarkable ability to repair itself when subjected to severe damage. Its behaviour resembles the regenerative power of some living organ...

Within the field of regenerative medicine, many have sought to use stem cells as a promising way to heal human tissue; however, in the past few years, exosomes (packaged vesicles released from cells) have shown more exciting promise. Specifically, stem cell-derived exosomes have demonstrated great ability to provide therapeutical benefits. Exosomal products can include miRNA, other genetic prod...

. The treatment of sports injuries to the point of restoration of full sports performance is an obvious goal in sports medicine. However, healing is the preferred goal because returning connective tissue to normal strength allows for a durable return to full sports performance. . Regenerative injection therapy (prolotherapy) is the injection of growth factors or growth factor production stimula...

Regenerative medicine has reached the point where we are performing clinical trials with stem-cell-derived cell populations in an effort to treat numerous human pathologies. However, many of these efforts have been challenged by the inability of the engrafted populations to properly integrate into the host environment to make a functional biological unit. It is apparent that we must understand ...

Markov models are commonly used to asses the dependability/performability of fault-tolerant systems. Computation of many dependability/performability measures for repairable fault-tolerant systems requires the transient analysis of irreducible Markov models. Examples of such measures are the unavailability at time and the -expected interval unavailability at time . Randomization (also called un...

Although regeneration of tissues occurs in all adult tetrapods, the ability to regenerate complex structures such as limbs is limited to urodeles (newts and salamanders). Given that many of the biological processes and the signaling pathways that control these processes are highly conserved among all tetrapods, it is likely that humans have the potential to regenerate structures in the same way...