reading development and instruction is a pedagogical priority at all academic levels. historically, in the educational field, numerous efforts have been made to facilitate the complex process of foreign language reading comprehension. more recently, increasing attention has been paid to the use of computers for developing reading comprehension skills and various efforts have been made in this r...

tall wheatgrass (agropyronelongatum) is native to iran and is used in a wide area of rangelands and also used in drylandseeding program. this plant produces green and dry fodder and has a great importance in protecting drylands from water and wind erosion.seed proteome analysis was conducted under three conditions, namley, optimum (20 °c and zero water potential), drought conditions (20 °c and ...

Phosphoinositide (PI) 3-kinases control essential cellular functions such as cytoskeletal dynamics, signal transduction and membrane trafficking. FYVE, PX and PH domains mediate the binding of effector proteins to the lipid products of PI 3-kinases. Recent studies have provided significant insights into the roles of PI 3-kinases, their catalytic products and their downstream effectors in membra...

Valproic acid (VPA) is a commonly used drug to treat epilepsy and bipolar disorders. Known properties of VPA are inhibitions of histone deacetylases and activation of extracellular signal regulated kinases (ERK), which cannot fully explain VPA's clinical features. We found that VPA induces the proteasomal degradation of DICER, a key protein in the generation of micro RNAs. Unexpectedly, the con...

Real-time imaging of regulated exocytosis in secreting organs can provide unprecedented temporal and spatial detail. Here, we highlight recent advances in 3D time-lapse imaging in Drosophila salivary glands at single-granule resolution. Using fluorescently labeled proteins expressed in the fly, it is now possible to image the dynamics of vesicle biogenesis and the cytoskeletal factors involved ...

Extracellular field potentials (EFPs) are an important source of information in neuroscience, but their physiological basis is in many cases still a matter of debate. Axonal sources are typically discounted in modeling and data analysis because their contributions are assumed to be negligible. Here, we established experimentally and theoretically that contributions of axons to EFPs can be signi...

Kinesin and myosin have been proposed to transport intracellular organelles and vesicles to the cell periphery in several cell systems. However, there has been little direct observation of the role of these motor proteins in the delivery of vesicles during regulated exocytosis in intact cells. Using a confocal microscope, we triggered local bursts of Ca 2 1 -regulated exocytosis by wounding the...