BACKGROUND Even after adequate immunosuppression therapy, acute rejection continues to be the single most important cause of graft dysfunction after renal transplantation. Renal allograft biopsy continues to be the reference standard, though certain clinical and biochemical parameters are helpful in assessment of these patients. Renal allograft rejection is mediated by T lymphocytes, expressing...

Immune rejections remain one of the most common causes of failure of penetrating keratoplasty. Epithelial rejection, chronic stromal rejection, hyperacute rejection and endothelial rejection constitute the different types of corneal graft rejection that might occur in isolation or conjunction. Various risk factors have been identified to increase the risk of graft rejections. With a recent adve...

INTRODUCTION Graft monitoring following vascularized composite allotransplantation (VCA) relies primarily on serial skin biopsy. However, given that VCA comprised multiple tissue types, skin biopsy may not accurately reflect rejection in other transplanted tissue. METHODS A review of the literature on episodes of both acute and chronic rejection following VCA was completed. Special attention ...

Chronic rejection remains the major obstacle to long term survival in heart transplant recipients. The cellular and molecular mechanisms that underlie chronic rejection are not known, and their discovery can form the basis of clinical intervention. Several investigators have suggested that the development of chronic rejection in solid organ transplants is dependent on help mediated by CD4(+) ly...

Background Postpartum Bonding Questionnaire (PBQ) is a remarkable tool to assess impairments in the mother-infant bonding. The purpose of the present study was to review the factorial structure of the PBQ cross different versions. Materials and Methods The search strategy was implemented on databases of Medline (via PubMed), Scopus, Cochran library and Web of Science through electronic database...

Background: Thymoglobuline (TG), is used for both induction and rejection therapy in kidney transplantation (TX). This study was conducted to compare between adding TG or not to the conventional drugs to evaluate the rate of rejections, infections and costs. Methods: In two groups of patients, each of 45 cases group A received conventional drugs (cyclosporine, mycophenolate and prednisolone) a...

Whether antibody-mediated rejection after lung transplantation exists as an entity is debated by immunologists, histopathologists, and clinicians, without a strong consensus regarding diagnostic characteristics despite an increasing body of evidence that attests to a significant role in other solid organ transplant disciplines. Evidence for and against the protean manifestations of antibody-med...

Earlier detection of antibody-mediated rejection of kidney allografts may improve graft outcomes. Profiling of gene expression holds promise for the diagnosis and prognosis of antibody-mediated rejection. Here, we identified 730 patients who received kidney transplants during 2002-2005, including 21 patients (2.9%) who experienced early acute antibody-mediated rejection. We also identified a ma...

OBJECTIVES We sought to use cardiac magnetic resonance (CMR) to establish sensitive and reliable indexes for noninvasive detection of acute cardiac allograft rejection. BACKGROUND Appropriate surveillance for acute allograft rejection is vitally important for graft survival. The current gold standard for diagnosing and staging rejection after organ transplantation is endomyocardial biopsy, wh...