in modern pharmacological medicine, saffron is used for various purposes due to its antioxidant effect. this study evaluated retinal function after treatment with saffron supplementation during a follow-up period of 6 months to provide further insight into the efficacy and safety considerations of this treatment. sixty patients with wet or dry age-related macular degeneration (amd) were randoml...

Due to the increasing relative incidences of age-related cataract and age-related macular degeneration (AMD) and the increasing longevity of the population, ophthalmologists are now frequently faced with the management of patients with both visually significant cataract and AMD. Our article focuses on pertinent aspects of IOL selection in this group of patients. Controversy exists regarding the...

Background Vascular endothelial growth factor (VEGF) is considered to play an essential role in the pathogenesis of agerelated macular degeneration due to its vascular permeability-inducing and angiogenic properties. Ranibizumab, a small antibody fragment designed to competitively bind all VEGF isoforms, passes after intravitreal injection into all retinal layers reaching the retinal pigment ep...

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly. Wet AMD includes typical choroidal neovascularization (CNV) and polypoidal choroidal vasculopathy (PCV). The etiology and pathogenesis of CNV and PCV are not well understood. Genome-wide association studies have linked a multifunctional serine protease, HTRA1, to AMD. However, the precise role ...

Age-related macular degeneration (AMD) is the most common geriatric eye disorder leading to blindness and is characterized by degeneration of the neuroepithelium in the macular area of the eye. Apolipoprotein E (apoE), the major apolipoprotein of the CNS and an important regulator of cholesterol and lipid transport, appears to be associated with neurodegeneration. The apoE gene (APOE) polymorph...

OCT angiography (OCTA) has been used to identify and characterize macular neovascularization (MNV) secondary age-related degeneration (AMD). 1 El Ameen A. Cohen S.Y. Semoun O. et al. Type 2 imaged by optical coherence tomography angiography. Retina. 2015; 35: 2212-2218 Crossref PubMed Scopus (104) Google Scholar , Kuehlewein L. Bansal M. Lenis T.L. Optical of type in degeneration. Am J Ophthalm...

Purpose A recent genome-wide association study by the International Age-related Macular Degeneration Genomics Consortium (IAMDGC) identified seven rare variants that are individually associated with age-related macular degeneration (AMD), the most common cause of vision loss in the elderly. In literature, several of these rare variants have been reported with different frequencies and odds rati...

Age-related macular degeneration (AMD) is the most common cause of vision loss in developed countries. A defining characteristic of this disorder is the accumulation of material between Bruch's membrane and the retinal pigment epithelium (RPE), first as microscopic basal deposits and later as clinically evident drusen. The pathogenesis of these deposits remains to be defined. Biochemical and ge...

Spontaneous closure of a full thickness macular holeis rare event and usually surgery is needed. A 71 year-old-woman had been followed with the diagnosis age related degeneration (AMD). Four years ago she complained sudden vision drop. Visual acuities were 0.05 1.0 in right left eyes, respectively. On optical coherence tomography examination hole dry type AMD detected her eye. During follow up ...

purpose: to determine the prevalence and determinants of age-related macular degeneration (amd) in a 40-64 year old iranian populationmethods: in a cross-sectional study, 6,311 people were randomly selected from shahroud. for all participants, visual acuity, refraction, slit-lamp examination and fundus photography were conducted under pupil dilation. results: results of this study are based on ...