Growing evidence suggests that n-3 PUFA and their specific lipid mediators can reduce the activity of inflammatory processes. In the present study, we evaluated the effects of oral n-3 PUFA supplementation on intestinal structural changes, enterocyte proliferation and apoptosis during methotrexate (MTX)-induced intestinal damage in the rat. A total of thirty-two male rats were divided into four...

The intestinal mucosal surface is in direct contact with a vast beneficial microbiota. The symbiotic nature of this relationship is threatened when the surface epithelium is injured, yet little is known about how mucosal surfaces maintain homeostasis with commensal microbes following damage. Intraepithelial lymphocytes ( IEL) reside at the gut epithelial surface, where they stimulate mucosal he...

Background and Aim: Oral mucosal lesions have various prevalence rates among different populations. Few studies have evaluated the frequency of oral mucosal lesions in Iranian population. This study aimed to determine the frequency of oral mucosal lesions and the related factors.                   &nb...

BACKGROUND Peptic ulcer disease, including its complications and functional dyspepsia, are prevalent gastrointestinal diseases, etiopathogenesis of which is associated with mucosal inflammation. Research into new therapeutics capable of preventing or curing gastrointestinal mucosal damage has been steadily developing over past decades. This study was undertaken to evaluate whether a spray-dried...

Background The total population health benefits and costs of HIV preexposure prophylaxis (PrEP) for people who inject drugs (PWID) in the United States are unclear. Objective To evaluate the cost-effectiveness and optimal delivery conditions of PrEP for PWID. Design Empirically calibrated dynamic compartmental model. Data Sources Published literature and expert opinion. Target Populatio...

Background It has been shown that genital lesions and altered innate mucosal immunity caused by HSV-2 are important cofactors to increase the rate of HIV transmission and infection. Therefore, a product that inhibits HIV and HSV would have potential benefits in the prophylaxis against these sexually transmitted viruses. The labyrinthopeptin A1 (LabyA1) is a prototype peptide of a novel class of...

1428 CMAJ, November 5, 2013, 185(16) © 2013 Canadian Medical Association or its licensors A35-year-old woman presented to the emergency department with a recurrent rash on the backs of both hands related to what she described as a “fever blister” on her lower lip. In the previous 2 years, she had experienced more than 12 similar eruptions involving both her lip and hands. She was not taking any...

Bovine virus diarrhoea-mucosal disease was described for the first time in the USSR in 1967. The disease occurs in 20 to 80% of farms, depending on geographic and climatic zones of the country. Control measures against the disease include quarantine restrictions and prevention by means of specific preparations of active and passive effect. Passive prophylaxis is conducted by aerosol methods for...

Background: Identifying risk factors for surgical site infection (SSI) after appendectomies could be useful in focusing prevention programs. Objective: The current study aimed to identify the risk factors associated with SSI in a cohort of patients from a single center in Western Qatar. Methods: This cross-sectional study was carrie...