It is known that secondary transporters, which utilize transmembrane ionic gradients to drive their substrates up a concentration gradient, can reverse the uptake and instead release their substrates. Unfortunately, the Michaelis-Menten kinetic scheme, which is popular in transporter studies, does not include transporter reversal, and it completely neglects the possibility of equilibrium betwee...

the aim of this work was to develop and evaluate a minoxidil foamable emu oil emulsion with the purpose of improving minoxidil permeation into the skin, increasing hair growth , reducing skin irritation, and increasing consumer compliance. minoxidil was dissolved in a solvent system comprising ethanol: glycerin: lactic acid: water (10:20:5:65). the foamable emulsion was prepared by mixing the o...

The paper proposes modeling calcein release kinetics (considered hydrophilic drug model) from interpenetrating network matrix of hydrogel type, based on combinations of two polymers, of which the chitosan is common. The release process is analyzed for different increasing time intervals, divided upon release kinetics evolution. For each time interval, a dominant release mechanism was identified...

The present study was oriented towards microencapsulation of aspirin and the study of its release kinetics. The desired encapsulation was achieved by emulsion solvent evaporation method using ethyl cellulose (EC), cellulose acetate phthalate (CAP) and their mixture (1:1) of polymeric constituents. Characterization of the formulations was performed by size, shape, drug loading efficiency and in-...

microencapsulation has become a common technique in the production of controlled release dosage forms. many results have been reported, concerning the use of alginate beads as controlled release drug formulations. alginate has a unique gel-forming property in the presence of multivalent cations, in an aqueous medium. ibuprofen is an excellent analgesic and antipyretic, non-steroidal anti-inflam...

The aim of this study was to develop an extended-release tablet formulation using a new in situ cross-linking method. The effects of polyvalent cations on theophylline release from tablets made with the polyanionic polymers sodium alginate and sodium carboxymethylcellulose, were investigated. Different miliequivalents of the di and tri-valent cation, Ca2+ and Al3+, were added to tablet form...

With the aim of optimizing Drug Eluting Stents (DES), particular attention has been laid on computational methods controlling drug release profile among researchers. Consequently, various models and simulations are available in literature. Nevertheless, validations based biorelevant in-vitro trials lacking. In present study, a comparison from polyurethane samples between calculated results expe...

this paper considers a class of one-dimensional solidification problem in which kinetic undercooling is incorporated into the temperature condition at the interface. a model problem with nonlinear kinetic law is considered. the main result is an existence theorem. the mathematical effects of the kinetic term are discussed

In this study, an in-house multi-dimensional code has been developed which simulates the combustion of n-heptane in a Homogeneous Charge Compression Ignition (HCCI) engine. It couples the flow field computations with detailed chemical kinetic scheme which involves the multi-reactions equations. A chemical kinetic scheme solver has been developed and coupled for solving the chemical reactions an...

The effect of neuronal uptake inhibition on basal interstitial release of norepinephrine in the canine heart was examined by use of the multiple tracer dilution-bulk balance technique. A kinetic model incorporating the effects of flow, capillary permeability-surface product for norepinephrine, the interstitial uptake rate constant for neurotransmitter, and plasma norepinephrine input and output...