Improved survival of critically ill acute renal failure patients can be correlated with therapy dose. The overall solute elimination can be measured by the product of clearance and time (Kt), which is usually normalized for the volume of distribution (V) of the solute as "Kt/V." Setting a Kt/V threshold of 1.4 can guide clinicians toward adequate treatment. This is a slightly higher prescriptio...

Corresponding Author: Mitra Mahdavi-Mazdeh, MD Management Center for Transplantation and Special Diseases, Vanak Sq, Tehran, Iran Tel: +98 21 8864 4515 Fax: +98 21 8864 4516 E-mail: [email protected] Dialysis and kidney transplantation are the only treatment options available for patients suffering from end-stage renal disease (ESRD). More than 1 million patients are on renal replacement ther...

Twenty-three patients with end-stage renal failure due to diabetic nephropathy received renal replacement treatment. All patients had insulin-dependent diabetes mellitus. Nineteen transplants were performed in seventeen patients. Two-year graft survival for all transplants was 74% with a two-year patient survival post-transplantation of 81%. Overall two-year patient survival was 73%, compared w...

Schetz M. Drug dosing in continuous renal replacement therapy: general rules. Curr Opin Crit Care 2007;13:645–51. Pea F, Viale P, Pavan F, Furlanut M. Pharmacokinetic considerations for antimicrobial therapy in patients receiving renal replacement therapy. Clin Pharmacokinet 2007;46:997–1038. Vandecasteele SJ, De Vriese AS. Recent changes in vancomycin use in renal failure. Kidney Int 2010;77:7...

Acute kidney injury is common in intensive care patients and continuous renal replacement therapy is the preferred treatment for this in most centres. Although these techniques have been adopted internationally, there remains significant variation with regard to their clinical application. This is particularly pertinent when one considers that the fundamental questions regarding any treatment, ...

Severe sepsis and septic shock cause considerable morbidity and mortality. Early appropriate empiric broad-spectrum antibiotics and advanced resuscitation therapy are the cornerstones of treatment for these conditions. In prescribing an antibiotic regimen in septic patients with acute renal failure treated with continuous renal replacement therapy, several factors should be considered: pharmaco...

More than 30 years ago diabetic patients with endstage renal disease (ESRD) were considered as inappropriate candidates for a chronic dialysis programme because of a very high mortality rate and poor longterm survival w1x. In spite of this negative attitude against diabetics on dialysis, not only more and more diabetic patients have been accepted to chronic renal replacement therapy, but diabet...

RESEARCH DESIGN AND METHODSdWe performed a single-center, prospective analysis in 1,088 T2D patients. RHR was determined at baseline by electrocardiogram. The primary outcome was a composite criterion of CV and renal morbi-mortality (CV death, nonfatal myocardial infarction and/or stroke, hospitalization for heart failure, renal replacement therapy), which was adjusted for death from non-CV cau...

BACKGROUND Renal failure with following continuous renal replacement therapy is a major clinical problem in liver transplant recipients, with reported incidences of 3% to 20%. Little is known about the significance of postoperative acute renal failure or acute-on-chronic renal failure to postoperative outcome in liver transplant recipients. METHODS In this post hoc analysis we compared the mo...