Background: Prolonged use of cyclosporine A for prevention of allograft rejection is associated with nephrotoxicity development. Naringenin and olive oil are beneficial dietary antioxidants with potential renoprotective properties. This study aimed to evaluate the therapeutic effect of naringenin and olive oil in alleviating cyclosporine induced nephrotoxicity in rats by the assessment of renal...

Abstract Radiation nephropathy is a rare complication following total body irradiation (TBI) and peptide receptor radionuclide therapy (PRRT). Yttrium 90-dotatoc (Y90) somatostatin analogue labelled with Y90 used for somatostatin-positive neuroendocrine tumours (NET). renally excreted has cumulative effect in the renal parenchyma Despite fractionation co-administration of renoprotective intrave...

In the June 2011 issue of the New England Journal of Medicine, the BEAM (Bardoxolone Methyl Treatment: Renal Function in CKD/Type 2 Diabetes) trial investigators rekindled new interest and also some controversy regarding the concept of renoprotection and the role of renoprotective agents, when they reported significant increases in the mean estimated glomerular filtration rate (eGFR) in diabeti...

Background & Aims: Numerous studies have reported the renoprotective effects of exercise in both human and animal models of diabetic nephropathy. However, detailed mechanism of action by which exercise has a favorable influence on renal fibrogenic factors is not yet fully understood. Therefore, the aim of this study was to assess the effect of swimming exercise on the activity ...

Dapagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, has been widely used in treatment of diabetic nephropathy (DN). Previous studies have shown that it both glucose-lowering effects and renoprotective functions DN. Tubulointerstitial fibrosis plays an important role the pathogenesis development progression Angiotensin‑converting enzyme (ACE2), major component renin-angiotensin sy...

Background Renoprotective effects of vitamin D analogues have been shown in several experimental and clinical studies, the exact mechanism therapeutic effectiveness these Nephrotic syndrome remains unclear, are relatively few studies on potential treatment roles for nephrotic-range proteinuria. ?ndicate similar efficacy calcitriol paricalcitol time-limited amelioration proteinuria nephrotic syn...

Large numbers of drugs are used in the treatment of hypertension and Calcium Channel Blockers are an important group among them. Cilnidipine is a new calcium channel blocking drug distinguished from other L-type calcium channel blockers with additional N-type of calcium channel blocking property. Cardioprotective, renoprotective and neuroprotective action of cilnidipine can provide additional b...