Previous findings have demonstrated a protective role for dopamine D(3)/D(2) receptor agonists in the convulsant and lethal effects of acutely administered cocaine. Data are provided here to establish that the protection occurs through a D(3)-linked mechanism and that protection is extended to seizure kindling. The D(3) antagonist SB-277011-A [4-quinolinecarboxamide,N-[trans-4-[2-(6-cyano-3,4-d...

Carnosine (beta-alanyl-l-histidine) has been characterized as a putative neurotransmitter. However, so far, understanding of the role of carnosine in the brain is very limited. The objective of this study was to examine the effects of carnosine on the development of pentylenetetrazol (PTZ) kindling seizures and protection against the PTZ kindled seizures in rats. Chemical kindling was elicited ...

Exposure to repetitive seizures is known to promote convulsions which depend on specific patterns of network activity. We aimed at evaluating the changes in seizure phenotype and neuronal network activation caused by a modified 6-Hz corneal stimulation model of psychomotor seizures. Mice received up to 4 sessions of 6-Hz corneal stimulation with fixed current amplitude of 32 mA and inter-stimul...

The performance of well established avoidance response was tested in cats with developed, kindled, bioelectric hippocampal epileptic focus and complex partial and secondarily generalized seizures. The animals were trained before kindling to perform foreleg movement in response to clicks (conditioning stimulus) in order to avoid an unconditioned stimulus - electric shocks, applied to the same fo...

Epilepsy is a neurological condition characterized by repeated seizures, which are clinical manifestations of abnormal electrical discharges in the brain. Epilepsy is the second most common neurological disorder in India. Epilepsy affects an estimated 7 million people in India, and 50 million worldwide. Approximately 40% of them are women. The prevalence of epilepsy is 0.7% in India, which is c...

Objective N/A. Background Leucine-Rich Glioma Inactivated Protein-1 (LGI1) autoimmune encephalitis was first described in 2001 as one of the syndromes caused antibodies against voltage-gated potassium channels (VGKC) until it discovered 2010 that were instead being directed towards protein LGI1. This often presents males their 60's and is associated with faciobrachial dystonic seizures, which h...

This study investigates procedures for controlling the familywise error rate (FWR) when testing hypotheses about multiple, correlated outcome variables in repeated measures (RM) designs. A content analysis of RM research articles published in 4 psychology journals revealed that 3 quarters of studies tested hypotheses about 2 or more outcome variables. Several procedures originally proposed for ...

Introduction This case-control study aimed to assess two single nucleotide polymorphisms of the gene encoding the GABRG2 protein - GABRG2 (3145 G>A) and GABRG2 rs 211037 Asn196Asn (C588T) - in a cohort of pediatric patients from Romania, and evaluate their possible impact on drug-resistant forms of generalized epilepsy and recurrent febrile seizures. Material and methods One hundred and fourt...