Genomics-based non-invasive prenatal screening using cell-free DNA (cfDNA screening) was proposed to reduce the number of invasive procedures in current prenatal diagnosis for fetal aneuploidies. We review here the clinical and ethical issues of cfDNA screening. To date, it is not clear how cfDNA screening is going to impact the performances of clinical prenatal diagnosis and how it could be in...

1. Merhej V, Georgiades K, Raoult D. Postgenomic analysis of bacterial pathogens repertoire reveals genome reduction rather than virulence factors. Brief Funct Genomics 2013;12:291–304. 2. Chua KY, Stinear TP, Howden BP. Functional genomics of Staphylococcusaureus. BriefFunctGenomics 2013; 12:305–15. 3. Tymoshenko S, Oppenheim RD, Soldati-Favre D, et al. Functional genomics of Plasmodium falcip...

Bioinformatics is a fast evolving field that combines biology, computer science, and statistics to analyze comprehend enormous volumes of biological data. As result the introduction high-throughput technologies like next-generation sequencing mass spectrometry, genomic proteomics research has generated data, necessitating development computational tools process extract useful insights from thes...

The green anole (Anolis carolinensis) is a lizard widespread throughout the southeastern United States and is a model organism for the study of reproductive behavior, physiology, neural biology, and genomics. Previous phylogeographic studies of A. carolinensis using mitochondrial DNA and small numbers of nuclear loci identified conflicting and poorly supported relationships among geographically...

Buffalo holds the unique potentiality among the livestock sector at tropical and subtropical area. The faster multiplication of superior genotypes and the conservation of endangered buffalo breeds are the important issue. Recent advances in assisted reproductive technologies (ART), including estrus/ovulation synchronization, multiple ovulation and embryo transfer (MOET), in vitro embryo product...

The detrimental effects of inbreeding on vertebrates are well documented for early stages of the life cycle in the laboratory. However, the consequences of inbreeding on long-term survival and reproductive success (Darwinian fitness) are uncertain for vertebrates in the wild. Here, we report direct experimental evidence for vertebrates that competition increases the harmful effects of inbreedin...

Protecting genome integrity against transposable elements is achieved by intricate molecular mechanisms involving PIWI proteins, their associated small RNAs (piRNAs), and epigenetic modifiers such as DNA methylation. Eusocial bees, in particular the Western honeybee, Apis mellifera, have one of the lowest contents of transposable elements in the animal kingdom, and, unlike other animals with a ...