Porcupines (Erethizon dorsatum) rely on trees and shrubs for winter food and can cause serious, localized damage to conifers. Twenty-two percent of ponderosa trees (Pinus ponderosa) examined in southeastern Washington were damaged by porcupines. Most damage involved complete girdling of the midto upper boles of the larger trees (12 to 30 cm dbh) in the stand. Preliminary repellent trials with c...

ZrB2-20 vol.% SiC-10 vol.% h-BN (particles) ceramic composites (ZSB) were fabricated by hot pressing under inert gas protected. ZSB samples with mean size 75 × 55 × 40 mm(3) were heated using current heating method and then cooled down to low temperature by circulating water. ZSB samples repeatedly went through thermal shock with 10-50 times under various conditions, respectively. Diverse effec...

Focused Ion Beam (FIB) has been demonstrated as a promising tool to the fabrication of microand nanoscale diamond cutting tools. In-depth understanding of the ion-solid interaction in diamond leading to residual damage under different processing parameters are in high demand for the fabrication of nanoscale diamond tools. Molecular dynamics (MD) simulation method has long been regarded as a pow...

The use of irinotecan to treat metastatic colorectal cancer (CRC) is limited by unpredictable response and variable toxicity; however, no reliable clinical biomarkers are available. Here, we report a study to ascertain whether irinotecan-induced DNA damage measures are suitable/superior biomarkers of irinotecan effect. CRC-cell lines (HCT-116 and HT-29) were treated in vitro with irinotecan and...

[This corrects the article on p. 65 in vol. 52, PMID: 28149394.].

The paper presents the results of a study on tree regeneration of forest stands in the Černý důl Nature Reserve, which is situated in the Orlické hory Mountains Protected Landscape area in the Czech Republic. Research was conducted in a spruce-beech stand with an admixture of silver fir, sycamore maple and rowan on two comparative permanent research plots (PRPs) (PRP 1—fenced enclosure and PRP ...

In order to examine the relationship between accumulation of residual DNA double-strand breaks (DSBs) and cell death, we have used a control and an ATM (Ataxia-Telangiectasia Mutated) defective cell line, as Ataxia-Telangiectasia (AT) cells tend to accumulate residual DSBs at long times after damage infliction. After irradiation, AT cells showed checkpoint impairment and a fraction of cells dis...

This work uses Monte Carlo simulations to investigate the dependence of residual and misrepaired double strand breaks (DSBs) at 24 hours on the initial damage pattern created during ion therapy. We present results from a nanometric DNA damage simulation coupled to a mechanistic model of Non-Homologous End Joining, capable of predicting the position, complexity, and repair of DSBs. The initial d...

Fine-grained isotropic graphite is the material of choice for the production target and the beam catchers at the planned Super-FRS fragment separator at FAIR. Heavyion irradiation studies of graphite are needed, as radiation damage will ultimately limit the lifetime of these components. Polycrystalline graphite and highly-oriented pyrolytic graphite (HOPG) were irradiated with energetic ions an...