نتایج جستجو برای: resistance to drugs
تعداد نتایج: 10753739 فیلتر نتایج به سال:
Association between ABCB1-T1236C Polymorphism and Drug-Resistant Epilepsy in Iranian Female Patients
Background: One third of epileptic patients are resistant to several anti-epileptic drugs (AED). P-glycoprotein (P-gp) is an efflux transporter encoded by ATP-binding cassette subfamily B member 1 (ABCB1) gene that excludes drugs from the cells and plays a significant role in AEDs resistance. Over-expression of P-gp could be a result of polymorphisms in ABCB1 gene. We studied the association of...
tuberculosis is an infectious disease caused by mycobacterium tuberculosis and is the primary cause of mortality in the world. m. tuberculosis strains are important intracellular pathogens causing infection in oxygen-rich macrophages in the lungs. the emergence of aids, declined socioeconomic standards and a lessened emphasis on tb control programs have contributed to the disease resurgence. re...
antimicrobial resistance in pathogens not only in hospitals but also in the community has become an important public health problem. the aim of this study was to determine the antimicrobial resistance patterns of predominant pathogens from hospitalized and outpatients in a university hospital in tehran, iran. a total of 820 samples of common gram-negative and gram-positive bacteria were collect...
Conventional drugs work, as a rule, by inhibiting the enzymatic activity of specific proteins, capping their active site. In this paper we present a model of non-conventional drug design based on the inhibiting effects small peptides obtained from segments of the protein itself have on the folding ability of the system. Such peptides attach to the newly expressed (unfolded) protein and inhibit ...
f America is to produce great painters, " wrote great American painter Thomas Eakins (1844–1916), young artists should " remain in America to peer deeper into the heart of American life " (1). Eakins traveled abroad, where he became familiar with the work of 19th-century greats Gustave Courbet, Édouard Manet, and Edgar Degas, but returned home to become a master of realism whose exactness and p...
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