BACKGROUND Hypertension is a risk factor for peripheral arterial disease (PAD). Subjects with PAD are at increased risk of future cardiovascular (CV) events. Resistin is involved in the pathological processes of CV diseases. The aim of this study is to investigate whether resistin level is correlated with PAD in hypertensive patients. METHODS One hundred and twenty-four hypertensive patients ...

To the Editor: Obesity, the most common nutritional disorder in industrialized countries, is associated with increased cardiovascular mortality and morbidity (1). C-reactive protein (CRP), an acutephase protein and an important predictor of future cardiovascular events in apparently healthy men and women (2), has been thought to be synthesized in the liver following stimulation by cytokines, su...

OBJECTIVES Few in vitro studies have examined the participation of resistin, a recently discovered adipokine, in oxidative processes. We investigated whether in vivo treatment with the antioxidant vitamin C might affect resistin serum levels. DESIGN Randomized prospective open trial. SETTING San Giovanni Battista Hospital, Turin, Italy. PARTICIPANTS Eighty healthy individuals. INTERVENT...

Intestinal preservation-reperfusion injury may result in various degrees of mucosal injury. Intestinal preservation-reperfusion injury may result in various degrees of mucosal injury. Interestingly, the preservation injury is similar when using the current preservation solutions, which are given as a intravascular flush. An extensive mucosal injury may ultimately preclude the use of organs that...

Resistin is an adipose-derived hormone that has been proposed as a link among obesity, insulin resistance, and diabetes. In agreement with a role of resistin in insulin resistance, the administration of recombinant resistin led to glucose intolerance in mice and impaired insulin action in rat liver. However, the regulation of resistin expression by physiological conditions, hormones, or agents ...

Resistin is known as an adipocyte-specific secretory hormone that can cause insulin resistance and decrease adipocyte differentiation. It can be regulated by sexual hormones, but the mechanism of estrogen’s actions is still not clear. Using 3T3-L1 adipocytes, we found that 17 -estradiol (E2) up-regulated resistin mRNA expression in a doseand time-dependent manner. The concentration of E2 that i...

Resistin is known as an adipocyte-specific secretory hormone that can cause insulin resistance and decrease adipocyte differentiation. It can be regulated by sexual hormones. Whether environmental estrogens regulate the production of resistin is still not clear. Using 3T3-L1 adipocytes, we found that octylphenol upregulated resistin mRNA expression in dose- and time-dependent manners. The conce...