Objective: International pharmacoeconomic studies suggest that functional impairment can be a significant predictor for the evaluation of direct and productivity costs for rheumatoid arthritis (RA). We calculated the direct and productivity costs for five Health Assessment Questionnaire (HAQ) groups of patients (HAQ scores o0.6, 0.6 Z 1.1, 1.1 Z 1.6, 1.6 Z 2.1, and Z2.1) in the Czech Republic. ...

AIMS To conduct a randomized, parallel group comparison of the population pharmacokinetics of the two methylprednisolone (MP) prodrugs Promedrol (MP suleptanate) and Solu-Medrol (MP succinate) in patients hospitalized with acute asthma. METHODS Ninety volunteers were included in the pharmacokinetic analysis. Each volunteer received a dosage regimen of 40 mg (MP equivalents) i.v. 6 hourly for ...

indian mustard is one of the most drought tolerant crops within brassica genus which could be used in semi dry areas of iran. 20 cultivars and lines of indian mustard were studied as complete blocks design with three replications in two different humidity regimes in oroumieh research station during 2013-2014 growing season. analysis of variance showed that the most studied agronomic characteris...

the complexity of the genetic control of drought tolerance makes inevitable using of molecular methods with biometric approaches to its improvement in plants. present study was conducted by 121 advanced lines and varieties of soybean under two moisture levels, normal and drought stress with 21 microsatellite markers linked to drought tolerance in two regions, namely, rasht and gonbad-kavous. gr...

With the pervasiveness and ubiquitous distribution of magnetic field in indoor environments, localization using positioning (MP) has attracted considerable attention. This work concentrates on MP pedestrian dead reckoning (PDR) method, constructs a fusion system for smartphones PDR based extended Kalman filter (EKF). The mind evolutionary algorithm (MEA) is introduced to search optimal position...

PURPOSE This study was undertaken to assess serial month-to-month consistency of macular pigment (MP) optical density and serum concentrations of lutein (L) and zeaxanthin (Z). Four healthy subjects aged between 23 and 51 years volunteered to participate in this study. METHODS MP optical density (measured psychophysically using heterochromatic flicker photometry [HFP]), and serum concentratio...

in order to comparison and determination of the best drought tolerance indices in sweet corn hybrids, an experiment was conducted using a randomized complete block design in split plot lay out with three replications at seed and plant improvement institute in karaj in 2006. three irrigation levels (irrigation after 75 as control, 100 and 125 millimeters cumulative evaporation from class a evapo...

In order to study seed yield and seed yield components in bean under reduced irrigation condition and assessment drought tolerance of genotypes, 15 lines of White beans were evaluated in two separate RCB design with 3 replications under stress and non stress conditions. Analysis of variance showed that there were significant differences among varieties in terms of traits under study, indicating...

A meta-analysis was conducted to decide whether to reduce an initial 6-mercaptopurine (6-MP) dose in TPMT heterozygote in the case of an initial 6-MP dose of <75 mg/m2/d and to compare the tolerable 6-MP dose among different ethnic groups. The study was undertaken according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The differences in mean values of the to...

The interaction of targeted drug carriers with epithelial and endothelial barriers in vivo is largely determined by the dynamics of the body fluids. To simulate these conditions in binding assays, a fully biocompatible in vitro model was developed which can accurately mimic a wide range of physiological flow conditions on a thumbnail-format cell-chip. This acoustically-driven microfluidic syste...