Objective(s): Response surface methodology (RSM) by central composite design (CCD) was applied to statistically optimize the preparation of Rutin-Quercetin (Ru-Qr) dual drug loaded human hair keratin nanoparticles as well as evaluate the characteristics. Materials and Methods: The effects of three independent parameters, namely, temperature (X1:10-40 C), surfactant (X2: SDS (1), SLS (2), Tween-...

The exact maximum likelihood estimate (MLE) provides a test statistic for the unit root test that is more powerful (Fuller, 1996, p. 577) than the usual least squares approach. In this paper a new derivation is given for the asymptotic distribution of this test statistic that is simpler and more direct than the previous method. The response surface regression method is used to obtain a fast alg...

In this paper, effects of critical parameters, namely initial gap, squeezing speed and applied current were statistically investigated on the mechanical behaviour of MR fluid in squeeze mode. A set of 17 experiments was designed using Design Expert 7 software to gather data from response surface methodology (RSM). The responses in terms of compression modulus were then calculated. An MRF132-DG ...

Rationalizing Boundedly Rational Choice: Sequential Rationalizability and Rational Shortlist Methods A sequentially rationalizable choice function is a choice function which can be obtained by applying sequentially a fixed set of asymmetric binary relations (rationales). A Rational ShortlistMethod (RSM) is a choice function which is sequentially rationalizable by two rationales. These concepts ...

Low Entropy Masking Schemes (LEMS) have been proposed to offer a reasonable tradeoff between the good protection against side-channel attacks offered by masking countermeasures and the high overhead that results from their implementation. Besides the limited analysis done in the original proposals of LEMS, their specific leakage characteristics have not yet been analyzed. This work explores the...

For any Lie algebra of classical type or type G 2 we define a K-theoretic analog of Dunkl's elements, the so-called truncated Ruijsenaars-Schneider-Macdonald elements, RSM-elements for short, in the corresponding Yang-Baxter group, which form a commuting family of elements in the latter. For the root systems of type A we prove that the subalgebra of the bracket algebra generated by the RSM-elem...

Cordycepin (3’-deoxyadenosine) is one of the most versatile metabolites of Cordyceps militaris due to its broad spectrum of biological activity. In this study, response surface methodology (RSM) was applied to optimize the medium components for the cordycepin production by submerged liquid culture. The optimal parameters for cordycepin production within the experimental range of the variables r...

The property of synergy and its detection are discussed. A response surface is said to possess synergy if it is monotone in each argument and its level curves are convex. Detecting this property is particularly useful in the study of combination drug therapies where the goal is enhanced response or diminished side effect. One way to detect synergy is to fit a surface with linear level curves un...

Genetic algorithms perform an adaptive search by maintaining a population of candidate solutions that are allocated dynamically to promising regions of the search space. The distributed nature of the genetic search provides a natural source of power for searching in changing environments. As long as sufficient diversity remains in the population the genetic algorithm can respond to a changing r...

A design methodology which uses a variable-complexity modeling approach in conjunction with response surface approximation methods has successfully been developed. This approach uses simple models to improve the accuracy of the response surface and reduce the number of analyses based on complex models required for constructing the surface. Simple models are rst used to eliminate \nonsense" port...