We synthesized a new water-soluble tribenzotriquinacene-based hexacarboxylate (TBTQ-C6, or H) which can associate with an azobenzene-containing amphiphile (trans-AZO) to form the H ⊃ trans-AZO supra-amphiphile by host-guest interactions in water. This further self-assembles into photo and pH dual-responsive vesicles. The reversible conversion between vesicles micelles be easily controlled both ...

Polyurethanes have been broadly used as biomaterials in tissue repair and regeneration due to their preeminent biocompatibility mechanical properties. However, traditional polyurethanes are not able efficiently cope with the complexity of dynamic microenvironments during process disease therapy. Physiologically responsive responding or reacting biological signals pathological abnormalities can ...

The controlled delivery of active pharmaceutical ingredients to the site disease represents a major challenge in drug therapy. Particularly when drugs have be transported across biological barriers, suitable systems are importance. In recent years responsive been developed which enable release depending on internal or external stimuli such as changes pH, redox environment light and temperature....

in this study, poly(ethylene-co-vinyl alcohol) (evoh) as a novel biocompatible polymeric scaffold was surface modified by succinylation to get evohs and further pegylated to improve structural properties using methoxypolyethylene glycol (5000 da) succinate (pegs) along with targeting with retinoic acid (ra) to get final modified active and passive targeted conjugate (pegs-evohs-ra) to evaluate ...

Intelligent drug-delivery systems are described as novel technological innovations and clinical approaches to improve conventional treatments. These systems differ in methodology of therapeutic administration, intricacy, materials and patient compliance to address numerous clinical conditions that require various pharmacological therapies. Drug delivery systems (DDS) capable of releasing an act...

conclusions this study demonstrated that physicochemical properties, in vitro release and rat intestine permeability were dependent upon the contents of s/c, water and oil percentage in formulations. background self-emulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, non-ionic surfactants or, one or more hydrophilic solvent and co-solvents/surfactant and polym...

objective(s): the aim of this work was to prepare and characterize magnetic nanoparticles (mnps) as theranostic system to act simultaneously as drug carrier and mri contrast agent. chitosan-coated mnps (cmnps) were prepared and loaded with silymarin. silymarin-loaded cmnps were characterized with various techniques and their potential as mri contrast agent was also evaluated. materials and meth...

Amphiphilic molecules, comprising hydrophobic and hydrophilic moieties the intrinsic propensity to self-assemble in aqueous environment, sustain a fascinating spectrum of structures functions ranging from biological membranes ordinary soap. Facing challenge design responsive, adaptive, out-of-equilibrium systems water, incorporation photoresponsive motifs amphiphilic molecular offers ample oppo...