Cancer recurrence is associated with treatment failure and is the main cause of death, 1 and thus remains to be a major clinical challenge. elevated level of the cyclin-dependent kinase 1 (CDK1) correlates with cancer recurrence and treatment resistance in patients with breast cancer or colorectal cancer. 2,3 it is proposed that defects in CDKs may lead to the accumulated genetic defects, which...

This article analyses quiescence search in an imperfect-information game, Stratego. We point out that there are two key problems. The first problem is the search overhead, and the second problem is the limited information gain. A possible solution to the first and second problem is an Evaluation-Based Quiescence Search (EBQS). Experiments show that this solution improves the playing strength of...

Epigenetic strategies control the orderly acquisition and maintenance of neuronal traits. A complex network of transcriptional repressors and co-repressors mediates gene specificity for these strategies. In this issue of Cell, a study by Ballas and coworkers (Ballas et al., 2005) provides insight into the early lineage commitment events during neurogenesis. This study demonstrates that regulati...

single-particle process Consider a single particle of volume V ( t ) at time t which undergoes random, discontinuous “erosion” to smaller sizes in accord with the probabilistic law: Pr( V ( t + d t ) I u I V ( f ) = u’ 1 = B ( u I u’ )dt We let F( u, t ) be the cumulative distribution function for the size of the single particle undergoing random erosion. Suppose that the cumulative probability...

Aims. EX Lup is the prototype of EXors, a subclass of low-mass pre-main sequence stars whose episodic eruptions are attributed to temporarily increased accretion. In quiescence the optical and near-infrared properties of EX Lup cannot be distinguished from those of normal T Tau stars. Here we investigate whether it is the circumstellar disk structure which makes EX Lup an atypical Class II obje...

Like all microorganisms, yeast cells spendmost of their natural lifetime in a reversible, quiescent state that is primarily induced by limitation for essential nutrients. Substantial progress has been made in defining the features of quiescent cells and the nutrient-signaling pathways that shape these features. A view that emerges from the wealth of new data is that yeast cells dynamically conf...

The Region-Time-Length (RTL) algorithm has been applied to different instrumental catalogues to detect seismic quiescence before medium-to-large earthquakes in Italy in the last two decades. RTL performances are sensitive to the choice of spatial and temporal parameters. The method for automatic parameters selection developed by Chen and Wu has been applied to 12 Italian earthquakes with magnit...