Abstract Background Resting‐state connectivity allows for investigating brain network changes in pathologic states of aging, such as Alzheimer’s Disease (AD). Recently, have been associated with AD‐related risk factors asymptomatic individuals. We explored how is affected by one factor, apolipoprotein e4 ( APOE4) carrier status. Methods In a sample cognitively healthy older adults (n=102), we a...

Complex neural modules with embedded neural development and synaptic plasticity features have been connected to form a hierarchical recurrent circuit. Virtual electrodes have been used to record a “neural” generated signal, called electrochipogram EChG, from each module. The EChG are processed by frequency domain methods to determine the modifications in functional connectivity by assessing qua...

Sagi Perel, Andrew B. Schwartz, and Valérie Ventura Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania; Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania; Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; and Department of Statistics, Carnegie Mellon University,...

Energy requirements have traditionally been determined based on multiples of resting metabolic rate (RMR), known as Physical Activity Levels (PAL). With more data from doubly labelled water studies alternative approaches for estimating energy requirements have been suggested. Statistical analysis reveals that body weight explains more of the variance in total energy expenditure (TEE) than does ...

We combined measures of resting-state functional magnetic resonance imaging and diffusion tensor imaging (DTI) to investigate alterations of function-structure relationships in patients with early-onset schizophrenia. DTI analysis revealed reduced fractional anisotropy in right frontal white matter. Corresponding gray matter regions showed reduced functional connectivity with other regions in t...

Recent studies of the structural and functional development of the human brain over the early years have highlighted the rapid development of brain structures and their interconnectivity. Some regional functional specializations emerge within the first months after birth, while others have a more protracted course of development spanning over the first decade or longer. While some anatomical ch...

Physical activity leads to a respiratory behaviour that is very different to a resting state and that influences speech production. How speech parameters are exactly affected by physical activity remains largely unknown. Hence, we investigated how several prosodic parameters change under influence of physical activity and focused on temporal and breathing characteristics which have not been add...

BACKGROUND N-terminal pro-brain natriuretic peptide (NT-proBNP) is associated with an increased risk of cardiac insufficiency, which possibly leads to heart failure. However, the relationship between resting heart rate and NT-proBNP is unclear. OBJECTIVE This study focuses on this relativity between resting heart rate and plasma NT-proBNP levels in a surveyed community-based population. MET...

The transition from adolescence to adulthood is a critical stage in the human lifespan during which the brain still undergoes substantial structural and functional change. The changing frequency composition of the resting state EEG reflects maturation of brain function. This study investigated (post)adolescent brain maturation captured by two independently but simultaneously recorded neuronal s...