The aim of this research was to formulate effervescent floating drug delivery systems of theophylline using different release retarding polymers such as ethyl cellulose, Eudragit® L100, xanthan gum and polyethylene oxide (PEO) N12K. Sodium bicarbonate was used as a gas generating agent. Direct compression was used to formulate floating tablets and the tablets were evaluated for their physicoche...

The overall objective of the present work was to develop an oral sustained-release (SR) Metformin tablet that is prepared by direct compression method using hydrophilic hydroxyl propyl methyl cellulose (HPMC) and Guar gum polymer alone as well in combination at different concentrations. a biguanide has relatively short plasma half-life. It low absolute bioavailability. All properties were evalu...

The objective of the study was to enhance the solubility of carvedilol phosphate and to formulate it into non-effervescent floating tablets using swellable polymers. Solid dispersions (SD) of carvedilol were prepared with hydrophilic carriers such as polyvinylpyrrolidone and poloxamer to enhance solubility. Non-effervescent floating tablets were prepared with a combination of optimized solid di...

L-3,4-Dihydroxyphenylalanine (DOPA) is an unusual amino acid found in mussel adhesive proteins (MAPs) that is believed to lend adhesive characteristics to these proteins. Most previous efforts to incorporate DOPA into hydrogels have utilized oxidative cross-linking, which is hypothesized to reduce the adhesive properties of DOPA and requires reagents that are harmful to biological tissues. In t...

An analysis system has been designed and built to characterise liquid metal ion source beams. Both mass and angular resolved energy distribution measurements can be made, from which both FWHM energy spreads and energy deficits can be obtained. This paper briefly describes the system and presents and discusses the first off-axis results taken with a gallium liquid metal ion source. Liquid metal ...

OBJECTIVES The aim of this study was to investigate the possibility of production of ibuprofen pellets with high amount of rate retarding polymer by aid of PEG400 as plasticizer. MATERIALS AND METHODS Polyethylene glycol (PEG400) in concentrations of 1, 3 or 5% w/w with respect to Eudragit RL was used in production of pellets containing 60% ibuprofen and 40% excipient (2% polyvinylpyrrolidone...

BESIDES their beneficial effect in retarding or arresting the growth of certain types of neoplasms, a number of anticancer drugs may cause impairment of antibody synthesis and cell-mediated immunity. These immunosuppressive effects have been used therapeutically to prevent and control rejection of organ homografts and also to treat a variety of clinical states. However, the anticancer agents ha...