Lipid-based nanocarriers have been extensively investigated for drug delivery due to their advantages including biodegradability, biocompatibility, nontoxicity, and nonimmunogenicity. However, the shortcomings of traditional lipid-based such as insufficient targeting, capture by reticuloendothelial system, fast elimination limit efficiency therapeutic efficacy. Therefore, a series multifunction...

Spleen is a major component of the reticuloendothelial system and functions as a filtering system for the encapsulated bacteria especially in children. Knowing the spectrum of conditions leading to splenectomy in any geographic area is important to decrease the number of unnessesary splenectomies. Here we report the causes of splenectomy in three major general referring hospitals in Shiraz, ...

The half-life of an intravenously injected bolus of intralipid 20% was measured in normal rats in order to asess its relationship to reticuloendothelial system (RES) activity. Groups of animals were studied following various treatments, and the results compared to measurement of carbon clearance in similar groups. The RES effects of silica and C parvum were confirmed by the carbon clearance tes...