Activated retina-specific T cells that have acquired the ability to break through the blood-retinal barrier are thought to be causally involved in autoimmune uveitis, a major cause of human blindness. It is unclear where these autoreactive T cells first become activated, given that their cognate antigens are sequestered within the immune-privileged eye. We demonstrate in a novel mouse model of ...

Abstract – Retinal is a chromophore of foremost relevance for potential applications in bio-photonics devices. Here, we study the degenerate two-photon absorption spectrum of all-trans retinal in ethanol. We observed two peaks; one associated to the twophoton dipolar contribution to a higher energy state, which contributes to the monotonic increase of the nonlinearity below 600 nm. The other on...

PURPOSE Seprafilm, a sodium hyaluronate/carboxymethylcellulose absorbable barrier developed to prevent adhesions after abdominal surgery, adheres well to wet tissue. The authors studied the efficacy of this film for sealing retinal breaks in animals. METHODS In an in vitro study, a retinal detachment with a hole was created in bovine eyecups after the vitreous gel was removed. Seprafilm was p...

PURPOSE Sirtuin1 (Sirt1) is an NAD(+)-dependent deacetylase involved in development, cell survival, stress resistance, energy metabolism, and aging. It is expressed in the mammalian central nervous system (CNS) and is activated during processes associated with neuroprotection. The retinal degeneration 10 (rd10) mouse model of retinitis pigmentosa (RP) was used to investigate the possible role o...

Linking the activity of neurons, circuits and synapses to human behavior is a fundamental goal neuroscience. Meeting this challenging, in part because behavior, particularly perception, often masks complexity underlying neural circuits, significant behavioral differences between primates animals like mice flies which genetic manipulations are relatively common. Here we relate circuit-level proc...

Rarely, do we think of cancer as “bacterial”, such that we are often told that “cancer is NOT contagious” Persistent bacterial infections cause persistent irritation of the host’s defense systems, which when ineffective in eradication of the infection, result in a multitude of self-destructive damages. This in some cases occurs to such severity that the resu...

This article represents a synthesis of an extensive literature review and the authors' decades-long personal experience with both scleral buckling (SB) and vitrectomy for rhegmatogenous retinal detachment (RD). Presenting a coherent understanding of the pathophysiology and treatment of RD, the authors confirm numerous findings described in earlier publications but also challenge certain long-st...

rarely, do we think of cancer as “bacterial”, such that we are often told that “cancer is not contagious” persistent bacterial infections cause persistent irritation of the host’s defense systems, which when ineffective in eradication of the infection, result in a multitude of self-destructive damages. this in some cases occurs to such severity that the resulting cellular hyper-proliferation pr...