OBJECTIVE To examine the relationship of retinal vascular caliber with diabetes, glycemia, and diabetic retinopathy. RESEARCH DESIGN AND METHODS Population-based study using data from the Multi-Ethnic Study of Atherosclerosis (MESA), comprising 5,976 individuals (whites, blacks, Hispanics, and Chinese) residing in six U.S. communities who were free of clinical cardiovascular disease at baseli...

Diabetes is a disease that occurs when the body presents an uncontrolled level of glucose capable damaging retina, leading to permanent damage eyes or vision loss. When diabetes affects eyes, it known as diabetic retinopathy, which became global medical problem among elderly people. The fundus oculi technique involves observing eyeball diagnose check pathology evolution. In this work, we implem...

The onset of diabetic retinopathy correlates with the long-term quality of glycemic control. A 17-yr-old adolescent with type 1 diabetes presented unexpectedly with acute non-proliferative retinopathy despite good glycemic control. Two months later chronic myeloid leukemia (CML) was diagnosed. Chemotherapy was initiated and within a few weeks the patient was in full remission concerning leukemi...

AIM To determine the prevalence of diabetic retinopathy in patients with Down's syndrome and diabetes mellitus. METHODS Nine patients with Down's syndrome and diabetes mellitus were assessed. Factors recorded included type and duration of diabetes, level of diabetic control, blood pressure, urinalysis, and results of ophthalmological examination. RESULTS The duration of diabetes ranged from...

Diabetic retinopathy is a complication of diabetes and a leading cause of blindness in the world. It occurs when diabetes damages the tiny blood vessels inside the retina. The main two types of diabetic retinopathy the first are non-proliferate diabetes retinopathy (NPDR) and second are proliferate diabetes retinopathy (PDR). Images analysis by trained individuals, which can be a very costly an...

OBJECTIVE To determine whether immunocomplexes (ICs) containing advanced glycation end product (AGE)-LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS Levels of AGE-LDL and oxLDL in ICs were measured in 517 patients of the Diabetes Control and Complications Trial/Epidemiology ...

Vascular endothelial dysfunction is a basic etiologic factor for the development of late clinical complications in patients with diabetes mellitus type 1, such as diabetic retinopathy, diabetic nephropathy (which is characterized at the very beginning by microalbuminuria), and left ventricular cardiac dysfunction. The aims of this study were to determine the prevalence of asymptomatic left vent...

OBJECTIVE To evaluate the incidence of diabetic retinopathy in patients with Type 2 Diabetes Mellitus, to identify the risk factors associated with the incidence of retinopathy and to develop a risk table to predict four-year retinopathy risk stratification for clinical use, from a four-year cohort study. DESIGN The MADIABETES Study is a prospective cohort study of 3,443 outpatients with Type...

Substantial data indicate that oxidative stress is involved in the development of diabetic retinopathy. Two candidate genes that affect the oxidative stress are manganese mitochondrial superoxide dismutase (Mn-SOD) and endothelial nitric oxide synthase (eNOS). The aim of the present study was to examine the role of the V16A polymorphism of the Mn-SOD gene and the 4a/b polymorphism of the eNOS g...