BACKGROUND Presence of retro-aortic left renal vein poses special challenge in creating spleno-renal shunt potentially increasing the chance of shunt failure. The technical feasibility and successful outcome of splenectomy with proximal spleno-renal shunt (PSRS) with retro-aortic left renal vein is presented for the first time. The patient was treated for portal hypertension and hypersplenism d...

Isolated acute bulbar palsy has been described as one of the more rare variants of Guillain-Barré syndrome. IgG anti-ganglioside antibodies are associated with axonal subtypes of Guillain-Barré syndrome as well as Fisher syndrome. However, IgG against GM3 and GT1b in relation to bulbar palsy is uncommon. In this case report, we describe a 64 year-old male patient presenting with isolated bulbar...

When the catalytic A subunits of the castor bean toxins ricin and Ricinus communis agglutinin (denoted as RTA and RCA A, respectively) are delivered into the endoplasmic reticulum (ER) of tobacco protoplasts, they become substrates for ER-associated protein degradation (ERAD). As such, these orphan polypeptides are retro-translocated to the cytosol, where a significant proportion of each protei...

Electron reflection at an interface is a fundamental quantum transport phenomenon. The most famous electron reflection is the electron→hole Andreev reflection (AR) at a metal/superconductor interface. While AR can be either specular or retro-type, electron→electron reflection is limited to only the specular type. Here we show that electrons can undergo retro-reflection in bilayer graphene (BLG)...

The retro-ene reaction is a common reaction of metastable immonium ions, leading to the expulsion of an alkene molecule. The kinetic energy release that accompanies this reaction decreases with alkyl substitution on the γ-carbon of the immonium ion. A number of authors have taken this result to indicate that the retro-ene reaction proceeds in a non-concerted manner via a carbocation intermediat...

随意運動は主として上位運動ニューロン，下位運動ニューロン，骨格筋により制御されるが，そのうち下位運動ニューロンが選択的に変性する疾患が下位運動ニューロン疾患であり，その代表的なものが球脊髄性筋萎縮症と脊髄性筋萎縮症である．両疾患はいずれも遺伝性疾患であり，分子病態に即した疾患修飾治療法が開発・実用化され，リアルワールドエビデンスの構築に向けた研究も進んでいる．さらに脊髄性筋萎縮症については，新生児スクリーニングによる発症前の診断・治療が進んでいる．

The regenerated epithelium derived from limbal epithelium was histologically and biochemically compared with epithelia regenerated from corneal and bulbar conjunctival epithelia. The histologic results indicated that regenerated epithelium of limbal origin increased in thickness with time after healing and showed no goblet cell appearance on the cornea. This suggests that regenerated epithelium...

AIM To compare and evaluate the success rates of various surgical techniques of pterygium excision, including pterygium excision with complete suture of conjunctivae (PESC), pterygium excision with conjunctival auto-graft transplantation with graft from the inferior temporal bulbar conjunctiva (ITBC) and pterygium excision with conjunctival auto-graft transplantation with graft from the superio...