STUDY QUESTION Is the ovarian response to controlled ovarian stimulation (COS) related to the ongoing pregnancy rate when taking into account the main covariates affecting the probabilities of pregnancy following fresh embryo transfer? SUMMARY ANSWER In patients treated with corifollitropin alfa or daily recombinant FSH (rFSH) in a GnRH-antagonist protocol, a high ovarian response did not com...

Abstract STUDY QUESTION Does the presence of single nucleotide polymorphisms (SNPs) in FSH receptor gene (FSHR) and/or beta subunit-encoding (FSHB) influence ovarian response predicted normal responders treated with rFSH? SUMMARY ANSWER The FSHR SNPs (rs6165, rs6166, rs1394205) has a statistically significant impact response, although this effect is minimal clinical relevance fixed dose 150 IU ...

The advent of recombinant technology has made the production of modified proteins with desired properties possible. Corifollitropin alfa is a successful example of the first available long-acting, follicle stimulating hormone. Corifollitropin alfa has prolonged half-life and a slower absorption rate, but has the same receptor-binding and biological activity as recombinant FSH (rFSH). Its applic...

background: the omega-3 fatty acid (ω-3 fatty acid) such as eicosapentaenoic acid (epa) is currently used in the clinic as a nutritional supplement in the treatment of polycystic ovarian syndrome (pcos). the present study was designed to investigate the effect of epa on the expression levels of peroxisome proliferator-activated receptor gamma (pparγ) and cytochrome p450 aromatase (encoded by th...