Neutrophil motility is crucial to effective host defenses against microorganisms. While uropod retraction is a critical step in the migration of neutrophils, the underlying molecular mechanism is not well understood. Here, we show that inhibition of the Rho small GTPase with C3 exoenzyme prevented the retraction of trailing uropods, indicating that the process of rear release is mediated by a R...

Cadherins are calcium-dependent adhesion molecules responsible for the establishment of tight cell-cell contacts. p120 catenin (p120ctn) binds to the cytoplasmic domain of cadherins in the juxtamembrane region, which has been implicated in regulating cell motility. It has previously been shown that overexpression of p120ctn induces a dendritic morphology in fibroblasts (Reynolds, A.B. , J. Dani...

Chronic inhibition of endothelial NO synthesis by the administration of N(G)-nitro-L-arginine methyl ester (L-NAME) to rats induces early vascular inflammation (monocyte infiltration into coronary vessels and monocyte chemoattractant protein-1 expression) as well as subsequent arteriosclerosis. The small GTPase Rho controls cell adhesion, motility, and proliferation and is activated by several ...

S. Martin, S. Basu, D. Schaafsma, A.J. Halayko, Department of Physiology, Faculty of Medicine, University of Manitoba and Manitoba Institute of Child Health, Winnipeg, MB Caveolin-1 (Cav-1) can modulate intracellular signaling pathways in airway smooth muscle (ASM) that may mediate inflammation, contraction, and/or proliferation. Previously, we observed enhanced methacholine (MCh)induced ASM co...

Cells migrate in multiple different ways depending on their environment, which includes the extracellular matrix composition, interactions with other cells, and chemical stimuli. For all types of cell migration, Rho GTPases play a central role, although the relative contribution of each Rho GTPase depends on the environment and cell type. Here, I review recent advances in our understanding of h...

in this paper, we introduce a new concept of - -ϕ-contractive integral type mappings and establish some new xed point theorems in complete metric spaces.

The classic equation for decomposing the wavefront aberrations of axis-symmetrical optical systems has form, $$ W({h}_0,\rho,\phi )=\sum_{j=0}^{\propto } \sum_{p=0}^{\propto \sum_{m=0}^{\propto {C}_{\left(2j+m\right)\left(2p+m\right)m}({h}_0{)}^{2j+m}(\rho {)}^{2p+m}(\mathrm{cos}\phi {)}^m where j , p and m are non-negative integers, ρ ϕ polar coordinates pupil, h 0 is object height. However, o...

Abstract. Let L and M be two finite lattices. The ideal J(L,M) is a monomial ideal in a specific polynomial ring and whose minimal monomial generators correspond to lattice homomorphisms ϕ: L→M. This ideal is called the ideal of lattice homomorphism. In this paper, we study J(L,M) in the case that L is the product of two lattices L_1 and L_2 and M is the chain [2]. We first characterize the set...

In the central nervous system inhibitory neurotransmission is primarily achieved through activation of receptors for gamma-aminobutyric acid (GABA). Three types of GABA receptors have been identified on the basis of their pharmacology and electrophysiology. The predominant type, termed GABAA and a recently identified type, GABAC, have integral chloride channels, whereas GABAB receptors couple t...