Activation of phagocyte NADPH oxidase requires interaction between p47 and p22. p47 in resting phagocytes does not bind p22. Phosphorylation of serines in the p47 C terminus enables binding to the p22 C terminus by inducing a conformational change in p47 that unmasks the SH3A domain. We report that an arginine/lysine-rich region in the p47 C terminus binds the p47 SH3 domains expressed in tande...
