A cell-scaled microbead system was used to analyze the force-dependent kinetics of P-selectin adhesive bonds independent of micromechanical properties of the neutrophil's surface microvilli, an elastic structure on which P-selectin ligand glycoprotein-1 (PSGL-1) is localized. Microvillus extension has been hypothesized in contributing to the dynamic range of leukocyte rolling observed in vivo d...

The integrin lymphocyte function-associated antigen-1 (alpha(L)beta(2)), which is known for its ability to mediate firm adhesion and migration, can also contribute to tethering and rolling in shear flow. The alpha(L) I domain can be mutationally locked with disulfide bonds into two distinct conformations, open and closed, which have high and low affinity for the ligand intercellular adhesion mo...

The kinetics of rolling and transient adhesions through selectins may depend on the kinetics and mechanical properties of the selectin:ligand bond, as well as on cellular properties including receptor-anchoring to the cell membrane and cytoskeleton. Kinetics are known to depend on the selectin and may also be ligand dependent. Here, we study the kinetics of transient and rolling interactions of...

The plastic penetration condition and biting-in condition of a radial conical ring rolling process with a closed die structure on the top and bottom of driven roll, simplified as RCRRCDS, were established. The reasonable value range of mandrel feed rate in rolling process was deduced. A coupled thermomechanical 3D FE model of RCRRCDS process was established. The changing laws of equivalent plas...

When multiple arms are used to manipulate a large object, it is beneficial and sometimes necessary to maintain and control contacts between the object and the effector (the contacting surface of an arm) through force closure. Rolling and/or sliding can occur at these contacts, and the system is characterized by holonomic as well as nonholonomic (including unilateral) constraints. In this paper,...

The selectins are transmembrane, Ca(2+)-dependent lectins that mediate leucocyte rolling on vascular surfaces, the first adhesive step during inflammation and immune surveillance. Leucocytes express L-selectin, activated platelets express P-selectin, and activated endothelial cells express E- and P-selectin. Rolling involves force-regulated, rapidly reversible interactions of selectins with a l...

Limited by the deficiency of the finite element method (FEM) to deal with infinite domain problems, the traditional FEM rolling model is not suitable enough to study the effect of the complex internal stress of the incoming strip on hot rolling deformation. To solve this problem, the finite element and infinite element (FE-IE) coupling method is adopted, where the finite element is for the roll...

This article gives a brief overview of the fracture contacting parts under influence circumferential force in meshing accompanied by rolling and slipping during plastic deformation.