Pancreatic cancer is the fourth leading cause of cancer-related death in the United States. Reactive oxygen species (ROS) are generally increased in pancreatic cancer cells compared with normal cells. ROS plays a vital role in various cellular biological activities including proliferation, growth, apoptosis, and invasion. Besides, ROS participates in tumor microenvironment orchestration. The ro...

The circadian system is composed of a number of feedback loops, and multiple feedback loops in the form of oscillators help to maintain stable rhythms. The filamentous fungus Neurospora crassa exhibits a circadian rhythm during asexual spore formation (conidiation banding) and has a major feedback loop that includes the FREQUENCY (FRQ)/WHITE COLLAR (WC) -1 and -2 oscillator (FWO). A mutation in...

Aims The cardiac ryanodine receptor (RyR) Ca2þ release channel homotetramer harbours 21 potentially redox-sensitive cysteine residues on each subunit and may act as a sensor for reactive oxygen species (ROS), linking ROS homeostasis to the regulation of Ca2þ signalling. In cardiac myocytes, arrayed RyRs or Ca2þ release units are packed in the close proximity of mitochondria, the primary source ...

The ROS navigation stack has become a crucial component for mobile robots using the framework. It is powerful, yet requires careful fine tuning of parameters to optimize its performance on given robot, task that not as simple it looks and potentially time-consuming. This tutorial chapter presents guide beginners aims serve reference “how” “why” when setting value key parameters. covers paramete...