نتایج جستجو برای: rossa autoantibodies
تعداد نتایج: 16277 فیلتر نتایج به سال:
Clinical implications of p53 autoantibodies in the sera of patients with non-small-cell lung cancer.
BACKGROUND The presence of autoantibodies to p53 protein has been associated with the presence of p53 (also known as TP53) gene mutations in primary tumors and with poor prognosis. This study was undertaken to determine the clinical significance of p53 autoantibodies in patients with non-small-cell lung cancer (NSCLC). METHODS We studied 188 consecutive patients with NSCLC who underwent pulmo...
BACKGROUND A protein that is expressed on capillary endothelial cells, called GPIHBP1 (glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1), binds lipoprotein lipase and shuttles it to its site of action in the capillary lumen. A deficiency in GPIHBP1 prevents lipoprotein lipase from reaching the capillary lumen. Patients with GPIHBP1 deficiency have low plasma leve...
Fig. S1. Immunoblot analysis using purified human laminin-332. Lane 1 is for IgG autoantibodies of anti-laminin-332 MMP control, lane 2 for IgG autoantibodies of normal control, lane 3 for patient IgG autoantibodies, and lane 4 for patient IgA autoantibodies. Both IgG and IgA from the patient reacted with the 165-kDa and 145-kDa forms of α3 subunit, as well as the 105-kDa γ2 subunit of laminin-...
ported criteria of S/LC -cTnI 6.7 or S/LC -cTnT 5.3 (1, 2 ). Taken together, 55 (15.9%) of the 345 samples were positive for autoantibodies to cardiac troponin I or T isoforms. In these positive samples, 10.9% (6 of 55) were positive for both autoantibodies. The odds of being positive for both autoantibodies increased in the presence of either species; in samples positive for autoantibodies to ...
Recent studies have shown that insulin autoantibodies occur in patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM) before exogenous insulin treatment. Our study was designed to test the hypothesis that insulin autoantibodies, like cytoplasmic islet cell antibodies (ICAs), can identify individuals with ongoing autoimmune beta-cell destruction and increased risk of IDDM devel...
Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM.
Individuals with systemic lupus erythematosus and rheumatoid arthritis are characterized by the presence of high levels of circulating IgM and IgG autoantibodies. Although IgG autoantibodies often are pathogenic, the role of IgM autoantibodies in autoimmune disease is not clear. Using mice that are unable to secrete IgM but are able to express surface IgM and IgD and to secrete other classes of...
Autoimmune liver diseases are conditions of low prevalence that comprise the triad of autoimmune hepatitis, primary biliary cholangitis (cirrhosis) and primary sclerosing cholangitis and their poorly characterised overlapping syndromes. Diagnostic autoantibodies are associated with autoimmune hepatitis and primary biliary cholangitis but not with primary sclerosing cholangitis. Autoantibodies a...
Background—Autoantibodies directed against the b1-adrenergic receptor have been described in patients with dilated cardiomyopathy. These autoantibodies exert an agonistic, chronotropic effect on spontaneously beating cultured neonatal rat cardiomyocytes. We studied the effect of such antibodies on b1-adrenergic receptor expression. Methods and Results—Cardiomyocytes were incubated with either t...
L UPUS ANTICOAGULANTS, and “antiphospholipid” autoantibodies in general, are of considerable clinical importance because of their strong association with thrombosis, recurrent fetal loss, and thrombocytopenia, ie, the “antiphospholipid” antibody syndrome.’ This review focuses on recent evidence that “antiphospholipid” autoantibodies are not directed against anionic phospholipids, as has previou...
OBJECTIVE Description of the various autoantibodies that can be detected in patients with systemic lupus erythematosus (SLE). METHODS A literature review, using the terms "autoantibody" and "systemic lupus erythematosus", was conducted to search for articles on autoantibodies in SLE, their target antigens, association with disease activity, or other clinical associations. RESULTS One hundre...
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