A 35 year-old woman referred to Royan Institute (Reproductive Biomedicine Research Center) for infertility treatment. She had an eleven-year history of primary infertility with a normal abdominal ultrasound. Hysterosalpingography (HSG) was obtained one month prior to referral in another center (Fig A). The HSG finding of an apparent unicorn uterus followed by a normal vaginal ultrasound led us ...

Background We sought to compare diagnostic values of two-dimensional transvaginal sonography (2D TVS) and office hysteroscopy (OH) for evaluation of endometrial pathologies in cases with repeated implantation failure (RIF) or recurrent pregnancy loss (RPL). MATERIALS AND METHODS This prospective study was performed at Royan Institute from December 2013 to January 2015. TVS was performed befor...

BACKGROUND During spermatogenesis, the H2B family, member W (H2B.W) gene, en- codes a testis specific histone that is co-localized with telomeric sequences and has the potential role to mediate the sperm-specific chromatin remodeling. Previously H2B.W genetic variants were reported to be involved in susceptibility to spermatogenesis im- pairment. In the present study, two single nucleotide poly...

ObjectiveTo investigate and compare growth potential as well as aging of mesenchymal stem cells (MSCs) derived from rat bone marrow tissue and adipose tissue (AT) occurred at epicardial and epididymal regions. DesignExperimental study. Animals10 Wistar Rats. ProceduresRat MSCs occurred at bone marrow and epicardial and epididymal AT were isolated and culture expanded through several successive ...

Background Globozoospermia is a rare but severe teratozoospermia disorder which causes male infertility. Total globozoospermia is diagnosed by the presence of 100% roundheaded spermatozoa lacking an acrosome in semen analysis. Recent studies have shown that in large majority of globozoospermic patients, deletion of a 200 kb segment including the DPY19L2 gene occurs. Among all the genes in this ...

Ovarian Hyperstimulation Syndrome (OHSS) is a rare complication of super ovulation and in vitro fertilization (IVF). Although our understanding of its pathophysiology is incomplete, induction of development of multiple follicles, perturbation of the renin angiotensin system and exposure to luteinizing hormone (LH) or human chorionic gonadotropin (hCG) are essential contributing factors to its d...

Background Leptin, as a key hormone in energy homeostasis, plays an important role in reproduction and male fertility. However, its negative or positive effect on sperm quality and assisted reproduction technique is still controversial. The aim of this study was the comparison of seminal leptin concentration in selected couples with male and female factor for intracytoplasmic microinjection (IC...