INTRODUCTION Alcohol-induced neuroinflammation is mediated by pro-inflammatory cytokines and chemokines including tumor necrosis factor-α (TNFα), monocyte chemotactic protein-1 (MCP1) and interleukin-1-beta (IL-1β). Toll-like receptor-4 (TLR4) pathway induced nuclear factor-κB (NF-κB) activation is involved in the pathogenesis of alcohol-induced neuroinflammation. Inflammation is a highly regul...

PURPOSE To investigate the effect of transforming growth factor (TGF)-beta2 on the expression of (1) elastin and type VI collagen (ColVI), (2) extracellular matrix (ECM)-degrading matrix-metalloproteinases (MMPs) and regulators of their activity/activation, and (3) the involvement of connective tissue growth factor (CTGF) in the TGF-beta2-mediated regulations in cultured human type-1A and -1B o...

Many researches are published and still going on for the effects of comorbidities coronavirus disease 2019 (COVID-19), but large studies cancer as a risk factor severity covid-19 in patients lacking. The aim this study was to see prevalence covid- 19 observe pattern course undergoing active treatment. In study, 50 RTPCR confirmed were enrolled who visited department from 1may September 2020 ret...

Background: Mucormycosis is lethal angio invasive fungal infection affecting mainly the immunocompromised individuals. During second wave of COVID-19 pandemic there was rise in number rhino-orbito-cerebral (ROCM) cases both affected patients and who recovered from infection. This study conducted to know anatomical site extent involvement head neck region vaccinated unvaccinated Methods: A retro...

Background: COVID-19 caused havoc on the mankind. Post effects were also very painful. symptoms affected almost every organ system of body not only physically, but had a profound effect psyche different individuals. We studied prevalence anxiety and depression in post phase. Materials methods: All patients attending various outpatient Departments, who positive RTPCR for COVID-19, more than 3 mo...

Corona virus disease 2019 (COVID-19) was declared as pandemic by WHO on March 10, 2020. Several countries around the globe have seen a two-wave pattern of reported cases. India is witnessing unprecedented spike in COVID-19 cases again since 2021 especially Maharashtra. Newer insights pathogenesis diseases, diagnosis and treatment modalities continue to evolve case novel infection. To study comp...

osmotic stress is one of the major factors that significantly reduce yields in dry areas. plants respond to this abiotic stress at physiological and molecular levels. many genes are induced under stress conditions by transcription factors. dehydration responsive element binding (dreb) protein is a subfamily of ap2/erf transcription factors which control expression of many osmotic stress-inducib...

Objective: To review the current diagnostic methodology available for Coronavirus Disease 2019 (COVID-19) caused by new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Method: This critically analyses merits and limitations of recent COVID-19 diagnostics being used disease prophylaxis its mitigation. Multiple research papers from 2019- 2022 were consulted. Many novel have been inc...

No abstract available. Article truncated after first 150 words. A previously healthy, 48-year-old woman, admitted with a working diagnosis of acute-on-chronic liver failure (Grade III) secondary to an autoimmune etiology, was found be SARS COV-2 RTPCR positive on routine admission screening. She initially managed standard medical care for COVID, including steroids. required invasive ventilation...

Introduction: The pandemic of Covid-19 was declared on 11 march 2020 by WHO. Methods: study carried out in a dedicated Covid 19 hospital 1493 patients. All patients who tested positive for RTPCR were included the and outcome analysed. Result: Most symptomatic (64.97%). asymptomatic recovered faster than difference statistically significant. most common symptoms fever (38.3%), tiredness (20.6%) ...